Results 131 to 140 of about 88,820 (301)
Advanced Science, EarlyView.We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang +11 more
wiley +1 more source
ChemEngineeringFed-batch and perfusion bioreactors are commonly used in biopharmaceutical production. This study applies mathematical models to investigate the influence of substrate concentration in the media added (Sm), operating substrate concentration in the ...
John J. Fitzpatrick +5 more
doaj +1 more source
, 2016 Fed-batch fermentation of glucose by R. ornithinolytica B6 (pBbA5c-budABC); ■, glucose; □, growth; ♢, ethanol; ●, acetoin; ○, 2,3-BD; ♦, acetic acid; ▲, succinic acid; △, lactic acid; +, butyric acid.
Jinwon Lee (83494) +6 more
core +1 more source
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Production of volatile fatty acids by batch, fed-batch and semi-batch anaerobic fermentation
, 1989 REYES, ELISA A. Institute of Chemistry, College of Arts and Sciences, University at the Philippines at Lao Banos, May 1420, Production of Volatile Fatty Acids from Coconut Skimmilk by Batch, Fed-Batch and Semi-Batch Anaerobic Fermentation.
Reyes, Elisa A
core
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
wiley +1 more source
Fed-Batch Fermentation using a Concentrated Medium
, 2008 To increase cell concentration and the production of alkaline protease, fed-batch cultures with standard medium (1x) or concentrated medium (2x or 5x) as feed were performed.
Usama Beshay, Beshay, Usama
core
Time course of batch and fed-batch bioconversion of acetoin from 2,3-butanediol.
, 2014 (A) Batch bioconversion; (B) fed-batch bioconversion.
Xian Zhang (191440) +7 more
core +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Advanced Science, EarlyView.Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source