Results 41 to 50 of about 5,560,090 (288)

Chronic coronary artery disease: regional characteristics of outpatient visits and hospitalizations of the Russian adult population

Кардиоваскулярная терапия и профилактика, 2023
Aim. To analyze hospitalizations and outpatient visits to primary health care facilities of patients aged 18 years and older with chronic coronary artery disease (CAD) by federal districts and the constituent entities of the Russian Federation from the ...
R. N. Shepel, A. A. Svishcheva, V. P. Lusnikov, A. V. Kontsevaya, O. M. Drapkina   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

NOTARIAL DISTRICT IN A FEDERAL TERRITORY

Notary, 2021
In connection with the creation of the federal territory ≪Sirius≫ the article provides an analysis of the proposed public authorities, taking into account the function of preventive justice performed by the Russian notary.
openaire   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Activities of Public Authorities of the North-West Federal District to Ensure Information Security

Управленческое консультирование, 2018
The article is considered the activities of public authorities of the North-West Federal District to ensure information security. Highlights the issues of formation and functioning of the information security system in the North-West Federal District ...
Mikhail Mikhailovich Kucheryavyy, Yury Vasilyevich Kosov, Yulia Vladimirovna Vovenda   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analysis of the Epidemiological Situation on Tularemia in 2024 and Forecast for 2025 in the Russian Federation

Проблемы особо опасных инфекций
147 human tularemia cases were registered on the territory of the Russian Federation (the relative incidence rate per 100,000 population is 0.1) in 20 regions of the country in 2024.
N. E. Gaevskaya, N. L. Pichurina, D. V. Trankvilevsky, O. N. Skudareva, I. E. Irishkova, N. V. Pavlovich, E. S. Kulikalova, E. N. Sokirkina, A. P. Khametova, A. A. Tushinsky, A. S. Krivenko, I. V. Savina, A. V. Tsai, M. V. Tsymbalistova, N. V. Aronova, V. M. Sorokin, A. S. Anisimova, R. S. Makhmudov, E. P. Sokolova, A. V. Mazepa, M. A. Borzenko, A. V. Kholin   +21 more
doaj   +1 more source