Design and Evaluation of Synthetic RNA-Based Incoherent Feed-Forward Loop Circuits [PDF]
Biomolecules, 2021 RNA-based regulators are promising tools for building synthetic biological systems that provide a powerful platform for achieving a complex regulation of transcription and translation.
Seongho Hong +5 more
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Identification of a Feed-Forward Loop Between 15(S)-HETE and PGE2 in Human Amnion at Parturition [PDF]
Journal of Lipid Research, 2022 Human parturition is associated with massive arachidonic acid (AA) mobilization in the amnion, indicating that large amounts of AA-derived eicosanoids are required for parturition. Prostaglandin E2 (PGE2) synthesized from the cyclooxygenase (COX) pathway
Fan Zhang, Kang Sun, Wang-Sheng Wang
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Targeting microglia-Th17 feed-forward loop to suppress autoimmune neuroinflammation [PDF]
Journal of NeuroinflammationMicroglia and Th17 cells are the major immunopathogenic cells in multiple sclerosis and its animal model of immune aspects, experimental autoimmune encephalomyelitis (EAE).
Jun Xiao +7 more
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A feed forward loop enforces YAP/TAZ signaling during tumorigenesis [PDF]
Nature Communications, 2018 The Hippo pathway is frequently dysregulated in cancer. Here, the authors identify NUAK2 as negative regulator of the Hippo pathway from a siRNA kinome screen and show that NUAK2 promotes YAP/TAZ nuclear localisation while NUAK2 is a transcriptional ...
Mandeep K. Gill +17 more
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A miR-9-5p/FOXO1/CPEB3 Feed-Forward Loop Drives the Progression of Hepatocellular Carcinoma [PDF]
Cells, 2022 Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, but its regulatory mechanism remains unclear and potential clinical biomarkers are still lacking.
Hui Hu +10 more
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Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits [PDF]
ACS Synthetic Biology, 2021 Jongmin Kim, Peng Yin, Tom F A de Greef
exaly +2 more sources
Synthetic feed-forward loop circuit boosts transgene expression in sugarcane [PDF]
Plant Cell ReportsStephen P Moose +2 more
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A mixed incoherent feed-forward loop allows conditional regulation of response dynamics. [PDF]
PLoS ONE, 2014 Expression of the SodA superoxide dismutase (MnSOD) in Escherichia coli is regulated by superoxide concentration through the SoxRS system and also by Fur (Ferric uptake regulator) through a mixed incoherent feed forward loop (FFL) containing the RyhB ...
Szabolcs Semsey
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Trade-offs and noise tolerance in signal detection by genetic circuits. [PDF]
PLoS ONE, 2010 Genetic circuits can implement elaborated tasks of amplitude or frequency signal detection. What type of constraints could circuits experience in the performance of these tasks, and how are they affected by molecular noise?
Raúl Guantes +3 more
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Systematic analysis of noise reduction properties of coupled and isolated feed-forward loops.
PLoS Computational Biology, 2021 Cells can maintain their homeostasis in a noisy environment since their signaling pathways can filter out noise somehow. Several network motifs have been proposed for biological noise filtering and, among these, feed-forward loops have received special ...
Suchana Chakravarty +1 more
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