Results 51 to 60 of about 1,187,747 (304)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Improving extracellular production of Serratia marcescens lytic polysaccharide monooxygenase CBP21 and Aeromonas veronii B565 chitinase Chi92 in Escherichia coli and their synergism

AMB Express, 2017
Lytic polysaccharide monooxygenases (LPMOs) can oxidize recalcitrant polysaccharides and boost the conversion of the second most abundant polysaccharide chitin by chitinase.
Yalin Yang, Juan Li, Xuewei Liu, Xingliang Pan, Junxiu Hou, Chao Ran, Zhigang Zhou   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Substitution Effects of Blue Sweet Lupin Grains as a Source of Protein in the Feed Ration on Milk Yield and the Chemical Composition of Fogera Dairy Cows

Advances in Agriculture
The high cost and limited availability of conventional protein supplements such as soybean cake (SBC) constrain dairy production in Ethiopia. This study evaluated the effects of substituting SBC with blue sweet lupin grain (BSLG) as a protein source on ...
Beyadglign Hunegnaw, Wondimeneh Mekonnen, Demelash Kassahun, Shigdaf Mekuriaw, Likawent Yeheyis, Adebabay Adane, Lissanework Mola, Desalegn Ayichew   +7 more
doaj   +1 more source

A Decision-Oriented Calibrated Screening Workflow for Tylosin Derivatives: Closed-Loop MIC Validation Against Staphylococcus aureus and Streptococcus agalactiae

Antibiotics
Background: Antimicrobial resistance among Gram-positive veterinary pathogens has increased the need for more rational and experimentally grounded strategies to prioritize tylosin derivatives for antibacterial development. This study aimed to develop and
Huan Liu, Yiming Liu, Na Yu, Miao An, Yaoxin Tang, Jing Qu, Xiubo Li   +6 more
doaj   +1 more source

A GH51 α-l-arabinofuranosidase from Talaromyces leycettanus strain JCM12802 that selectively drives synergistic lignocellulose hydrolysis

Microbial Cell Factories, 2019
Background The development of sustainable technologies for plant cell wall degradation greatly depends on enzymes with hydrolytic activities against carbohydrates.
Tao Tu, Xiaoli Li, Kun Meng, Yingguo Bai, Yuan Wang, Zhenxing Wang, Bin Yao, Huiying Luo   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Feed-response curves for spiked feed samples.

, 2016
Melamine concentration fortified in feed-response curves for feed samples spiked with melamine in the range 2−200 μg·g−1.
Yue Yao (421960), Caiqin Han (1463941), Xiao-Ou Su (466120), Yiping Zhao (250264), Shi Wang (116703), Jie Cheng (294193)   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Feed additives : annual report 2011 of the National Reference Laboratory [PDF]

, 2010
This report describes the activities employed by RIKILT regarding the functions as: - the National Reference Laboratory (NRL) for feed additives; - advice regarding temporary use exemptions, other advice and support of EL&I. This report also presents the
Jong, J., de, Driessen, J.J.M., de Jong, J., Beek, W.M.J.   +3 more
core