Results 61 to 70 of about 2,517,379 (295)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Physiological Control Law for Rotary Blood Pumps with Full-State Feedback Method

Applied Sciences, 2019
One concern about pulsatile rotary blood pumps is their physiological controller reactions when “venous return” changes. When a patient rises from a supine to a standing position, the blood volume in the leg veins is raised, owing to ...
Mohsen Bakouri
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Analysing user physiological responses for affective video summarisation [PDF]

, 2009
This is the post-print version of the final paper published in Displays. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other ...
Agius, H, Money, AG
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Effects of electroencephalography-based art therapy on emotion regulation difficulties, psychological well-being, relaxation and attention levels among college students

Humanities & Social Sciences Communications
College students face increasing psychological health challenges, yet effective emotion regulation interventions remain understudied. This study examines whether electroencephalography (EEG) feedback can enhance the effectiveness of art therapy for ...
Ling Wu, Shuxin Wang, Libo Yang, Xin Wu
doaj   +1 more source

Am I Top of the Pops? Does Feedback of Live GPS Between Sets of Hurling-Specific Small-Sided Games Improve Subsequent Running and Physiological Performance?

Applied Sciences
The investigation aimed to determine if live feedback of team- and player-specific global positioning system (GPS) running performance data between bouts of hurling small-sided games (SSGs) altered the physical and physiological responses during ...
Shane Malone, John Keane, Tom Hargroves, Conor P. Clancy, John David Duggan, Damien Young, Kieran D. Collins   +6 more
doaj   +1 more source

Potential Roles of Exercise in Regulating Myoendothelial Feedback in Resistance Arteries [PDF]

운동과학
PURPOSE Resistance arteries rely on tightly coordinated signaling between vascular smooth muscle cells (SMCs) and endothelial cells (ECs) to regulate vascular tone and ensure appropriate tissue perfusion.
Young-Min Park, Kwang-Seok Hong
doaj   +1 more source

Teaching methods in Physiology: Students’ Feedback

IOSR Journal of Research & Method in Education (IOSRJRME), 2014
BACKGROUND: The mainstream of tertiary education has seen a massive transformation over the last few decades and the move towards student centered learning is finding support in the physiological sciences. It is becoming increasingly urgent to find ways of evaluating teaching/learning strategies.
openaire   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source