Results 51 to 60 of about 2,517,379 (295)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Enhancing long-term adherence in elderly stroke rehabilitation through a digital health approach based on multimodal feedback and personalized intervention

Scientific Reports
Multimodal digital health technologies aim to improve long-term adherence in stroke patients through personalized feedback and psychological monitoring.
Xintong Wen, Yuxuan Li, Qi Zhang, Zhiwei Yao, Xijie Gao, Zhibo Sun, Xing Fang, Wei Huang   +7 more
doaj   +1 more source

Analysis of the Body Control System Related to Mental Workload

International Journal of Advanced Robotic Systems, 2012
In this paper, we present a model-based analysis of the standing posture control mechanism with consideration to mental workload and the physiological features of sensory feedback.
Seiji Naito, Youngwoo Kim, Goro Obinata
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

CONTROL-CORE: A Framework for Simulation and Design of Closed-Loop Peripheral Neuromodulation Control Systems

IEEE Access, 2022
Closed-loop Vagus Nerve Stimulation (VNS) based on physiological feedback signals is a promising approach to regulate organ functions and develop therapeutic devices.
Pradeeban Kathiravelu, Mark Arnold, Jake Fleischer, Yuyu Yao, Shubham Awasthi, Aviral Kumar Goel, Andrew Branen, Parisa Sarikhani, Gautam Kumar, Mayuresh V. Kothare, Babak Mahmoudi   +10 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Training-induced modulation of motor task performance and psychophysiological domains through augmented sensory feedback in virtual reality

Frontiers in Virtual Reality
BackgroundAugmented sensory feedback (ASF) in virtual reality (VR) can enhance motor performance, yet it is not standardly employed with rehabilitation protocols and its effects on physiological and perceptual states remain underexplored.AimThis study ...
Raviraj Nataraj, Raviraj Nataraj, Mingxiao Liu, Mingxiao Liu, Yu Shi, Yu Shi, Sophie Dewil, Sophie Dewil, Noam Y. Harel, Noam Y. Harel   +9 more
doaj   +1 more source