Results 71 to 80 of about 2,517,379 (295)

Noise management by molecular networks.

PLoS Computational Biology, 2009
Fluctuations in the copy number of key regulatory macromolecules ("noise") may cause physiological heterogeneity in populations of (isogenic) cells. The kinetics of processes and their wiring in molecular networks can modulate this molecular noise.
Frank J Bruggeman, Nils Blüthgen, Hans V Westerhoff   +2 more
doaj   +1 more source

Control strategy for anaesthetic drug dosage with interaction among human physiological organs using optimal fractional order PID controller

, 2014
In this paper, an efficient control strategy for physiological interaction based anaesthetic drug infusion model is explored using the fractional order (FO) proportional integral derivative (PID) controllers.
Koushik Maharatna, Das, Saptarshi, Sourav Das, Saptarshi Das, Das, Sourav, Maharatna, Koushik   +5 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Analyzing VR-based group discussions for timely speaking-intention feedback to leaders

Frontiers in Computer Science
IntroductionDespite advances in virtual reality (VR) devices, leaders in VR-based group discussions lack inclusive facilitation support. Speaking-intention cues are latent information indicating readiness to speak, yet they are difficult to perceive in ...
Chenghao Gu, Jiadong Chen, Tianyuan Yang, Feike Xu, Boxuan Ma, Shin'ichi Konomi   +5 more
doaj   +1 more source

Effect of disparities of feedback on pacing in cycle time trials [PDF]

, 2012
The purpose of this study is to understand the effect of hypoxia during warm-up and competition on performance during cycle time trials. Methods: Seven well-trained subjects performed a VO2max test, two habituation trials, and four randomly ordered ...
Nyberg, Katelyn E.
core  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Physiologically and Psychologically Based Tactile Perception of the Leaves of Two Common Ornamental Plants [PDF]

园林
Tactile perception, as an effective means of perceiving and experiencing plant landscapes, plays a role in promoting and improving human health. However, research on the tactile perception effects of different leaf types remains relatively scarce. Common
JIA Jie, WANG Xudong
doaj   +1 more source

VibroTac: An Ergonomic And Versatile Usable Vibrotactile Feedback Device [PDF]

, 2010
— This paper presents an ergonomic vibrotactile feedback device for the human arm. Due to the developed con- cept, the device can be used for a large spectrum of applications and a wide range of arm diameters since vibration segments are self ...
Ende, Tobias, Wüsthoff, Tilo, Schätzle, Simon, Preusche, Carsten   +3 more
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source