Results 71 to 80 of about 324,809 (306)

Proposal for a Framework for Optimizing Artificial Environments Based on Physiological Feedback [PDF]

Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science, 2005
We propose and then evaluate a new framework for finding the physical parameters of an artificial environment which give rise to given target physiological characteristics. We assume that a human is a system that takes as inputs the physical parameters of an artificial environment and outputs physiological parameters in response.
Takagi, Hideyuki, Wang, Shangfei, Nakano, Shota   +2 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dynamic Difficulty Level Adjustment Based on Score and Physiological Signal Feedback in the Robot-Assisted Rehabilitation System, RehabRoby

, 2021
In this letter, subjects take part in a fruit picker game on the robot-assisted rehabilitation system RehabRoby. The difficulty level of the game is adjusted using three feedback strategies.

core   +1 more source

Analyzing VR-based group discussions for timely speaking-intention feedback to leaders

Frontiers in Computer Science
IntroductionDespite advances in virtual reality (VR) devices, leaders in VR-based group discussions lack inclusive facilitation support. Speaking-intention cues are latent information indicating readiness to speak, yet they are difficult to perceive in ...
Chenghao Gu, Jiadong Chen, Tianyuan Yang, Feike Xu, Boxuan Ma, Shin'ichi Konomi   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Server-Based Mobile Coaching System

Sensors, 2010
A prototype system for monitoring, transmitting and processing performance data in sports for the purpose of providing feedback has been developed. During training, athletes are equipped with a mobile device and wireless sensors using the ANT protocol in
Hristo Novatchkov, Martin Tampier, Philipp Kornfeind, Sebastian Bichler, Emanuel Preuschl, Arnold Baca   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Physiological processes and gross energy budget of the submerged longline-cultured Pacific oyster Crassostrea gigas in a temperate bay of Korea.

PLoS ONE, 2018
Physiological processes and gross energy budget of the longline-cultured Pacific oyster Crassostrea gigas were investigated in Geoje-Hansan Bay, Korea during two entire culturing periods.
Young-Jae Lee, Eunah Han, Michael J Wilberg, Won Chan Lee, Kwang-Sik Choi, Chang-Keun Kang   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source