Results 71 to 80 of about 750,358 (301)

A perspective on the control of FES-supported standing [PDF]

, 1998
This special section is about the control of electrical stimulators to restore standing functions to paraplegics. It addresses several important topics regarding the interactions of the intact central nervous systems (CNS) with the artificial control ...
Donaldson, Nick, Veltink, Peter H.
core   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TR alpha 2 exerts dominant negative effects on hypothalamic Trh transcription in vivo. [PDF]

PLoS ONE, 2014
Mammalian thyroid hormone receptors (TRs) have multiple isoforms, including the bona fide receptors that bind T3 (TRα1, TRβ1 and TRβ2) and a non-hormone-binding variant, TRα2.
Hajer Guissouma, Rym Ghaddab-Zroud, Isabelle Seugnet, Stéphanie Decherf, Barbara Demeneix, Marie-Stéphanie Clerget-Froidevaux   +5 more
doaj   +1 more source

Brain–computer interface game applications for combined neurofeedback and biofeedback treatment for children on the autism spectrum [PDF]

, 2014
Individuals with Autism Spectrum Disorder (ASD) show deficits in social and communicative skills, including imitation, empathy, and shared attention, as well as restricted interests and repetitive patterns of behaviors.
Friedrich, Elisabeth V. C., Lim, Theodore, Louchart, Sandy, Pineda, Jaime A., Sivanathan, Aparajithan, Suttie, Neil   +5 more
core   +4 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Designing adaptive feedback systems for managing cognitive load in augmented reality

Design Science
Managing cognitive load is central to designing interactive systems, particularly within augmented reality (AR) environments that impose complex and immersive demands.
Jiacheng Sun, Ting Liao
doaj   +1 more source

Following one's heart: cardiac rhythms gate central initiation of sympathetic reflexes [PDF]

, 2009
Central nervous processing of environmental stimuli requires integration of sensory information with ongoing autonomic control of cardiovascular function.
Critchley, Hugo D, Gray, Marcus A, Harrison, Neil A, Rylander, Karin, Wallin, B Gunnar   +4 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Examining the Use of Glucose and Physical Activity Self-Monitoring Technologies in Individuals at Moderate to High Risk of Developing Type 2 Diabetes: Randomized Trial

JMIR mHealth and uHealth, 2019
BackgroundSelf-monitoring of behavior (namely, diet and physical activity) and physiology (namely, glucose) has been shown to be effective in type 2 diabetes (T2D) and prediabetes prevention.
Whelan, Maxine E, Orme, Mark W, Kingsnorth, Andrew P, Sherar, Lauren B, Denton, Francesca L, Esliger, Dale W   +5 more
doaj   +1 more source