Results 101 to 110 of about 1,918,001 (296)
Open PraxisSo much depends on online course participants’ ability to communicate in ways so that others can perceive their personalities and know that they are real people.
Jered Borup +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Media attention to climate change has been increasing over the past several years, but not all articles on the subject are entirely accurate, and it can sometimes be difficult for non-expert readers to separate the wheat from the misleading chaff.
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Beekeeper: Accelerating Honeypot Analysis With LLM-Driven Feedback
IEEE AccessHoneypots are decoy resources intended to entice adversaries and collect threat intelligence in the process. The amount and quality of the collected insights strongly correlate with the honeypot’s credibility to the adversary.
Niclas Ilg +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Comparing Teacher and Student Perceptions about Second Language Writing Feedback [PDF]
, 2008 This study examines the discrepancies between teachers’ and students’ perceptions on L2 writing feedback. In a survey of 47 students and six teachers at an English Intensive Program, it investigated whether teachers’ perceived satisfaction on part of ...
Johnstun, Ann
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Blended Feedback: Delivery of feedback as digital audio on a computer programming unit [PDF]
, 2013 Traditionally students are taught in a classroom, lecture theatre, or laboratory, by staff. They are encouraged to question, discuss, and participate in learning activities maximizing learning potential and to engage in dialogue as a means of monitoring ...
Atfield-Cutts, S., Jeary, S.
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External cavity mode structure of a two-mode VCSEL subject to optical feedback [PDF]
, 2007 We consider a multi-transverse-mode vertical-cavity surface-emitting laser (VCSEL) subject to optical feedback. The system is modeled by a partial differential equation for the spatial carrier population, which is coupled to delay differential equations ...
Green, K +5 more
core +1 more source