Results 71 to 80 of about 2,348,564 (281)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Faire descendre le maître de son piédestal. Retour sur parcours d’un formateur-chercheur

Éducation et Socialisation
This paper takes a look back at my teaching career, traced through the eyes of the ignorant master, a figure proposed by Jacques Rancière in the light of the work of Joseph Jacotot.
Philippe Glâtre
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Sound and vision: evaluating the student experience of audio-visual feedback in higher education

Journal of Learning Development in Higher Education
Technology enhanced feedback methods such as video feedback are increasingly employed with a notable shift towards embracing remote means of communication during and after the Covid-19 pandemic. Greater use of distance and electronic learning can result
Jill Gould, Patricia Day
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Konuşma Eğitimi Sürecinde Geri Bildirim Kaynakları

Uluslararası Filoloji Bengü
Bu çalışmanın amacı, öğrencilerin sözlü metin üretiminin her aşamasını verimli geçirmesinde öğretmen, akran ve öz değerlendirmeye dayalı geri bildirimin rolünü araştırmaktır.
Zeynal Abidin Elçi
doaj   +1 more source

Architects need environmental feedback [PDF]

, 2004
The role of environmental feedback within architects' offices is examined as a fundamental ingredient of sustainability. Three case study buildings are examined using a feedback exercise encompassing the whole building process from early key design ...
Andreu, IC, Isabel Carmona Andreu, Tadj Oreszczyn, Oreszczyn, T   +3 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Exploring Feedback Design Perceptions and Relationships with Scores in the Online Component of an EAP-Blended Course

Applied Sciences
This quantitative study investigates the perceptions of learners and faculty regarding the help provided by the feedback process, which aligns with and integrates Brooks et al.’s Matrix of Feedback for Learning in the asynchronous online component of a ...
Anna Moni, María-Jesús Martínez-Argüelles, Enric Serradell-López   +2 more
doaj   +1 more source

The Effects of Augmented Somatosensory Feedback on Postural Sway and Muscle Co-contraction in Different Sensory Conditions

Physical Therapy Korea, 2020
Background: Augmented somatosensory feedback stimulates the mechanoreceptor to deliver information on bodily position, improving the postural control. The various types of such feedback include ankle-foot orthoses (AFOs) and vibration.
Seo-hyun Kim, Kyung-eun Lee, One-bin Lim, Chung-hwi Yi   +3 more
doaj   +1 more source