Results 61 to 70 of about 1,822,010 (290)
Architects need environmental feedback [PDF]
, 2004 The role of environmental feedback within architects' offices is examined as a fundamental ingredient of sustainability. Three case study buildings are examined using a feedback exercise encompassing the whole building process from early key design ...
Andreu, IC +3 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Loop is delighted and honoured to announce that poet and playwright Adam Wyeth, who lives and works in Dublin, is as of June 2024 a patron of Loop. We look forward to continuing our conversation with Adam, begun at the excellent 2024 SAES Congress at ...
The LOOP team
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
On the capacity loss of closed-loop MIMO
Tongxin xuebao, 2005 In the closed-loop MIMO system model, the mathematic formulae between the closed-loop MIMO capacity loss and the feedback channel rate were deduced. Through simulation results, five important conclusions on the relations between the average SNR, antenna ...
ZHANG Duo, WEI Guo, ZHU Jin-kang
doaj +2 more sources
Sequential Loop Closure Based Adaptive Output Feedback
IEEE Access, 2017 This paper presents a new, systematic method of synthesizing an output feedback adaptive controller for a class of uncertain, non-square multi-input/multi-output systems. The control design process consists of first designing an inner-loop controller for
Daniel P. Wiese +4 more
doaj +1 more source
Stability of closed-loop fractional-order systems and definition of damping contours for the design of controllers [PDF]
, 2012 Fractional complex order integrator has been used since 1991 for the design of robust control-systems. In the CRONE control methodology, it permits the parameterization of open loop transfer function which is optimized in a robustness context.
Oustaloup, Alain +2 more
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Positive feedback loops and multistationarity
Discrete Applied Mathematics, 1988 The aim of the paper is to draw the attention of mathematicians to complex systems, frequent in biology and related fields, which comprise multiple feedback loops. Such systems may be described in terms of ordinary differential equations. Since most of these differential equations are non-linear, these systems can not be treated analytically.
Thomas, René, Richelle, Jean
openaire +3 more sources
Feedback methods for inverse simulation of dynamic models for engineering systems applications [PDF]
, 2011 Inverse simulation is a form of inverse modelling in which computer simulation methods are used to find the time histories of input variables that, for a given model, match a set of required output responses.
David J. Murray-Smith +1 more
core +1 more source