Results 51 to 60 of about 1,822,010 (290)

Selenium catalysis enables negative feedback organic oscillators

Nature Communications
The construction of materials regulated by chemical reaction networks requires regulatory motifs that can be stacked together into systems with desired properties. Multiple autocatalytic reactions producing thiols are known.
Xiuxiu Li, Polina Fomitskaya, Viktoryia A. Smaliak, Barbara S. Smith, Ekaterina V. Skorb, Sergey N. Semenov   +5 more
doaj   +1 more source

A positive feedback loop bi-stably activates fibroblasts

Nature Communications, 2018
Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback
So-Young Yeo, Keun-Woo Lee, Dongkwan Shin, Sugyun An, Kwang-Hyun Cho, Seok-Hyung Kim   +5 more
doaj   +1 more source

A tension-adhesion feedback loop in plant epidermis

eLife, 2018
Mechanical forces have emerged as coordinating signals for most cell functions. Yet, because forces are invisible, mapping tensile stress patterns in tissues remains a major challenge in all kingdoms. Here we take advantage of the adhesion defects in the
Stéphane Verger, Yuchen Long, Arezki Boudaoud, Olivier Hamant   +3 more
doaj   +1 more source

A High–Precision Motion Control Based on a Multi-Rate Periodic Adaptive Disturbance Observer of a Linear Actuator for High Load Systems

IEEE Access, 2020
This study is concerned with the problem of compensating for periodic disturbances under repetitive motion conditions. In order to achieve high precision positioning for high load systems with periodic disturbances, a practical motion control scheme ...
Kwanghyun Cho, Kanghyun Nam
doaj   +1 more source

A Patient Outcomes–Driven Feedback Platform for Emergency Medicine Clinicians: Human-Centered Design and Usability Evaluation of Linking Outcomes Of Patients (LOOP)

JMIR Human Factors, 2022
BackgroundThe availability of patient outcomes–based feedback is limited in episodic care environments such as the emergency department.
Alexandra T Strauss, Cameron Morgan, Christopher El Khuri, Becky Slogeris, Aria G Smith, Eili Klein, Matt Toerper, Anthony DeAngelo, Arnaud Debraine, Susan Peterson, Ayse P Gurses, Scott Levin, Jeremiah Hinson   +12 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma

Journal of Experimental & Clinical Cancer Research, 2019
Background Angiogenesis plays a critical role in the progression of glioma. Previous studies have indicated that RNA-binding proteins (RBPs) interact with RNAs and participate in the regulation of the malignant behaviors of tumors.
Zhenwei He, Xuelei Ruan, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, Jun Ma, Lianqi Shao, Di Wang, Shuyuan Shen, Chunqing Yang, Yixue Xue   +11 more
doaj   +1 more source

The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)

EBioMedicine, 2020
Summary: The pathogenesis of coronavirus disease 2019 (COVID-19) may be envisaged as the dynamic interaction between four vicious feedback loops chained or happening at once.
Pere Domingo, Isabel Mur, Virginia Pomar, Héctor Corominas, Jordi Casademont, Natividad de Benito   +5 more
doaj   +1 more source

D’univocité en rétroaction : la critique de la cybernétique dans la pensée de Heidegger

Tic & Société, 2021
The concept of information is central to philosopher Martin Heidegger’s work; we take advantage of this opportunity in order to better understand the movement of demediation in relation to the expansion of algorithmic logic.
Baptiste Rappin
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source