Results 41 to 50 of about 1,822,010 (290)

Feedback Loops of Attention in Peer Production [PDF]

2009 International Conference on Computational Science and Engineering, 2009
A significant percentage of online content is now published and consumed via the mechanism of crowdsourcing. While any user can contribute to these forums, a disproportionately large percentage of the content is submitted by very active and devoted users, whose continuing participation is key to the sites' success.
Fang Wu 0001, Dennis M. Wilkinson, Bernardo A. Huberman   +2 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Comparison of two electronic hand hygiene systems using real-time feedback via wireless technology to improve hand hygiene compliance in an intensive care unit

Antimicrobial Stewardship & Healthcare Epidemiology, 2022
Background: Most hand hygiene (HH) intervention studies use a quasi-experimental design, are primarily uncontrolled before-and-after studies, or are controlled before-and-after studies with a nonequivalent control group. Well-funded studies with improved
José R. Generoso, Eduardo Casaroto, Ary Serpa Neto, Marcelo Prado, Guilherme M. Gagliardi, Fernando Gatti de Menezes, Priscila Gonçalves, Fábio Barlem Hohmann, Guilherme Benfatti Olivato, Gustavo Potratz Gonçalves, Andréa Marques Pereira, Nathalia Xavier, Marcelo Fernandes Miguel, Elivane da Silva Victor, Michael B. Edmond, Alexandre R. Marra   +15 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Advanced process control in laser-based powder bed fusion–Smart Fusion feedback-loop control as a path to uniform properties for complex structures?

Journal of Materials Research and Technology
Laser-based powder bed fusion of metals (PBF-LB/M) enables the production of complex parts with high freedom of design. However, changes in cross-sectional area with build height influence inter-layer times and heat dissipation, resulting in potential ...
Florian Nahr, Tobias Novotny, Dominik Kunz, Ulrich Kleinhans, Lova Chechik, Dominic Bartels, Michael Schmidt   +6 more
doaj   +1 more source

(Re)inventing the Circadian Feedback Loop [PDF]

Developmental Cell, 2012
For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks have swelled to include dozens of ...
Brown Steven A, Kowalska Elzbieta, Dallmann Robert   +2 more
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Half-octave shift in mammalian hearing is an epiphenomenon of the cochlear amplifier. [PDF]

PLoS ONE, 2012
The cochlear amplifier is a hypothesized positive feedback process responsible for our exquisite hearing sensitivity. Experimental evidence for or against the positive feedback hypothesis is still lacking. Here we apply linear control theory to determine
Sripriya Ramamoorthy, Alfred L Nuttall
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source