Results 61 to 70 of about 1,278,700 (293)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

(Re)inventing the Circadian Feedback Loop [PDF]

Developmental Cell, 2012
For 20 years, researchers have thought that circadian clocks are defined by feedback loops of transcription and translation. The rediscovery of posttranslational circadian oscillators in diverse organisms forces us to rethink this paradigm. Meanwhile, the original "basic" feedback loops of canonical circadian clocks have swelled to include dozens of ...
Brown Steven A, Kowalska Elzbieta, Dallmann Robert   +2 more
openaire   +3 more sources

Using teacher-supported peer feedback to develop student feedback literacy in L2 writing: An instructional model [PDF]

, 2023
To realize the potential of feedback, students need to possess feedback literacy. Frequently implemented in writing classrooms, peer feedback activities carry unique potential for developing student feedback literacy. This paper proposes an instructional
Maggie Ma
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Long Form Improvisation, Feedback Loops and Cybernetics

Body, Space & Technology Journal, 2015
This is an edited and augmented transcript of a critically reflective discussion following performance-based research into the integration of theatre and dance improvisation practices and audible performance ecosystems.
Glenn Noble, Daren Pickles
doaj   +4 more sources

Robust Cascade Control inside a New Model-Matching Architecture

Mathematics, 2023
Whenever additional states of a plant can be measured, closing nested feedback loops can be exploited in a variety of ways. The goal here is to reduce the bandwidth of feedback controllers and thus reduce the amplification of sensor noise that can ...
Javier Rico-Azagra, Montserrat Gil-Martínez   +1 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Feedback mechanisms stabilise degraded turf algal systems at a CO2 seep site

Communications Biology, 2021
Ben Harvey et al. use the gradient provided by a natural CO2 seep off Shikine Island, Japan and lab microcosm experiments to determine how ocean acidification promotes turf algal habitat conditions that create stabilizing feedback loops and hysteresis ...
Ben P. Harvey, Ro Allen, Sylvain Agostini, Linn J. Hoffmann, Koetsu Kon, Tina C. Summerfield, Shigeki Wada, Jason M. Hall-Spencer   +7 more
doaj   +1 more source

Experimental validation of a predicted feedback loop in the multi-oscillator clock of Arabidopsis thaliana [PDF]

, 2006
Our computational model of the circadian clock comprised the feedback loop between LATE ELONGATED HYPOCOTYL (LHY), CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and TIMING OF CAB EXPRESSION 1 (TOC1), and a predicted, interlocking feedback loop involving TOC1 and a
Nagy, Ferenc, Turner, Matthew S., Andrew J Millar, Gould, Peter D, Anthony Hall, Locke, James C. W., Kozma-Bognar, Laszlo, Balázs Fehér, Ferenc Nagy, Hall, Anthony, Matthew S Turner, Kevei, Eva, László Kozma‐Bognár, Gould, Peter D., Turner, Matthew S, James C W Locke, Peter D Gould, Millar, Andrew J; id_orcid, Millar, A. J. (Andrew J.), Éva Kevei, Locke, James C W, Feher, Balazs   +21 more
core   +1 more source