Results 81 to 90 of about 1,278,700 (293)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Highlighting the role of biota in feedback loops from tundra ecosystems to the atmosphere
Frontiers in Environmental ScienceThe rapid climatic and environmental changes observed in the Arctic and across the globe in general call for reliable model projections. In recent years our understanding of ongoing and future changes through ecosystem modelling has increased ...
Niels M. Schmidt +6 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Experience Feedback Loops in the New Product Introduction Process
, 2017 Prior research has identified the reuse of past experiences as a remarkable driver for achieving high levels of maturity for both product and production systems. Many companies put effort into capitalizing their own experiences through nurturing feedback
Chirumalla, Koteshwar,
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Digital brand image management based on feedback loops
Модернизация, инновация, развитиеPurpose: is to propose a model for managing a digital brand image brand based on consecutive feedback loops from the image targetaudience. Methods: collection, processing, and analysis of secondary data were carried out on the basis of desk research ...
N. I. Ivashkova +2 more
doaj +1 more source
Feedback Realization of Open Loop Diagonalizers [PDF]
IFAC Proceedings Volumes, 1992 For a given full row rank transfer matrix (rational matrix function) \(Z(s)\) and a given \(p\times p\) strictly proper diagonal matrix \(\Lambda(s)\), the set of open loop \(\Lambda\)-diagonalizers, \(\text{OLD} (Z,\Lambda)\) is defined as \[ \text{OLD} (Z,\Lambda):= \{\text{proper } M(s)\mid Z(s) M(s)= \Lambda\}. \] Assuming the \(Z(s)= C(sI- A)^{-1}
openaire +5 more sources
, 2022 One model of serial acquisition relies on the acquirers enjoying a high price-earnings ratio which enables them to buy targets with lower price-earnings ratios, resulting in high earnings per share ratios which boost the share price and facilitate further mergers.
Geoff Meeks, J. Gay Meeks
openaire +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source