Results 71 to 80 of about 186,586 (268)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Modelling and compensation of rate‐dependent hysteresis in piezoelectric actuators based on a modified Madelung model

Electronics Letters
Based on the principle of weight superposition, a modified Madelung model is proposed. By combining the signal delay response characteristics (SDRC), a dynamic model and its inverse model are established to describe and compensate for the rate‐dependent ...
Rui Li, Kairui Cao, Zekun Li
doaj   +1 more source

Energy-Aware Validation of the PIDA Control in the Hardware-in-the-Loop Environment

Energies
The goal of this work is to compare the effectiveness of the classical PID (Proportional Integral Derivative) controller and its extended PIDA (Proportional Integral Derivative Acceleration) version in the energy-aware context.
Marcin Jabłoński, Paweł D. Domański
doaj   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Development of a Path Tracker Based on a 4WS Vehicle for Low-Speed Automated Driving Systems

Applied Sciences
With the increasing demand for various autonomous driving services in urban environments, low-speed autonomous vehicles, such as autonomous shuttles and purpose-built vehicles, equipped with enhanced driving characteristics suitable for urban roads ...
Heung-Sik Park, Moon-Sik Kim
doaj   +1 more source

Public feedback - but personal feedforward?

Journal of Learning Development in Higher Education, 2012
People can learn by considering and understanding examples. With assistance, students should see and appreciate in examples strengths on which they can build, and weaknesses which they should minimise. So feedback and feedforward to students can usefully
John Cowan, YiChing Jean Chiu
doaj   +1 more source

A stochastic optimal feedforward and feedback control methodology for superagility [PDF]

A new control design methodology is developed: Stochastic Optimal Feedforward and Feedback Technology (SOFFT). Traditional design techniques optimize a single cost function (which expresses the design objectives) to obtain both the feedforward and ...
Direskeneli, Haldun, Halyo, Nesim, Taylor, Deborah B.   +2 more
core   +1 more source