Results 91 to 100 of about 528,064 (267)

FEAR AND FEELING OF INSECURITY IN HOTELS AND HOST COMMUNITIES, IBADAN, NIGERIA [PDF]

open access: yesAnalele Universităţii din Oradea: Seria Geografie
The study examines fear and feeling of insecurity in Ibadan, Nigeria. Residents and staff of hotels were selected through multistage and purposive sampling respectively.
Gbenga John OLADEHINDE   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Logos estetico in Gentile

open access: yesAisthesis, 2017
Through an analysis of some crucial passages from Giovanni Gentile’s Sistema di logica come teoria del conoscere, Filosofia dell’arte, Introduzione alla filosofia and Genesi e struttura della società, the paper discusses the role and significance of the ...
Roberto Diodato
doaj  

Par sentiment de cœur. Polisemia di un luogo etico-antropologico pascaliano

open access: yesNoctua
The ‘heart’, an object of misunderstanding in a sentimentalist sense, condenses in Pascal’s thought a plurality of meanings that make it, in several respects, an anthropologically pregnant and fundamental ‘place’ for the understanding of his philosophy ...
Alberto Peratoner
doaj   +1 more source

The Sense of Security and Comfort in Education—Development, Validation, and Interpretation of a New Questionnaire

open access: yesEducation Sciences
The purpose of this study was to measure the sense of security and comfort (SSC) as a latent construct in compulsory education. Taking theoretical considerations into account, a questionnaire for primary and secondary schools was developed in several pre-
Matthias Huber, Christoph Helm
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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