Results 71 to 80 of about 778,919 (303)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

No Feelings [PDF]

open access: yes, 2019
Feelings can change just how seasons can ...
Guzman, Juan, Juan Guzman
core   +1 more source

Differences in evoked emotions, feelings and reactions to body and mouth odour

open access: yesIbom Medical Journal, 2018
Objective: To compare evoked emotions, feelings and reactions to body and mouth odour among undergraduates. Methods: This questionnaire-based cross-sectional study was conducted among undergraduates of the University of Benin, Benin City, Nigeria ...
Azodo CC, Ogbebor OG
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Durable Public Feelings

open access: yes, 2011
: Exploring the durability of feelings, and the relationship of feelings to publics, the first part of this paper maintains that the multiplicity of contradictory means for engaging the terms “public” and “feelings” indexes precisely the conflicts that ...
Michael Epp
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Positive emotional feelings.

open access: yes, 2017
Mean values of the positive emotional feelings (feelings of joy, feelings of kindness and the feeling of safety) during the treatments with the Body Monochord (BM) and CD-music in context of the chronological order of the presentation.
Matthias Rose (768156)   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ON THE FEELING OF UNREALITY [PDF]

open access: yesThe Journal of Nervous and Mental Disease, 1910
n ...
openaire   +2 more sources

GENERATING FACTORS OF FEELINGS TO PATIENTS INTO HOSPITAL IN FRONT OF SURGERIES CANCELLATION SITUATIONS [PDF]

open access: yesRevista Eletrônica de Enfermagem, 2002
The hospitalization is not an agreeable experience, being worsened if surgical intervention becomesnecessary. When the surgery is suspended, the person is subject to a larger discomfort, which can generate moreanguish.
Hérica Kelly Costa   +2 more
doaj  

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