Results 21 to 30 of about 12,702 (216)

The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus [PDF]

, 1999
Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting ...
Hosie, M.J., Willett, B.J.
core   +1 more source

Applications of the FIV Model to Study HIV Pathogenesis

Viruses, 2018
Feline immunodeficiency virus (FIV) is a naturally-occurring retrovirus that infects domestic and non-domestic feline species, producing progressive immune depletion that results in an acquired immunodeficiency syndrome (AIDS).
Craig Miller, Zaid Abdo, Aaron Ericsson, John Elder, Sue VandeWoude   +4 more
doaj   +1 more source

Upregulation of surface feline CXCR4 expression following ectopic expression of CCR5: implications for studies of the cell tropism of feline immunodeficiency virus [PDF]

, 2002
Feline CXCR4 and CCR5 were expressed in feline cells as fusion proteins with enhanced green fluorescent protein (EGFP). Expression of the EGFP fusion proteins was localized to the cell membrane, and surface expression of CXCR4 was confirmed by using a ...
Hosie, M.J., Willett, B.J., Cannon, C.A.
core   +1 more source

Mapping the domains of CD134 as a functional receptor for feline immunodeficiency virus (FIV) [PDF]

, 2006
The feline homologue of CD134 (fCD134) is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells.
Bonci, F., Hosie, MJ, Bonci F, Willett BJ, Hosie MJ, Bonci, F, McMonagle, E.L., Hosie, M.J., Pistello, M, McMonagle EL, McMonagle, EL, Willett, B.J., Willett, BJ, PISTELLO, MAURO, Pistello, M.   +14 more
core   +1 more source

FIV vaccine with receptor epitopes results in neutralizing antibodies but does not confer resistance to challenge

npj Vaccines, 2018
Feline immunodeficiency virus: In vivo protection remains elusive A vaccine candidate for feline immunodeficiency virus elicits strong immunological reaction in vitro, but no protection to live cats. The feline analog to human immunodeficiency virus, FIV
Craig Miller, Mauren Emanuelli, Elizabeth Fink, Esther Musselman, Ryan Mackie, Ryan Troyer, John Elder, Sue VandeWoude   +7 more
doaj   +1 more source

Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus [PDF]

, 2006
The feline homologue of CD134 (fCD134) is the primary binding receptor for feline immunodeficiency virus (FIV), targeting the virus preferentially to activated CD4+ helper T cells.
McMonagle, E.L., Hosie, M.J., Willett, B.J., Ridha, S.   +3 more
core   +1 more source

Serosurvey of mountain lions in southern Arizona

Wildlife Society Bulletin, 2012
An understanding of the prevalence of diseases in free‐ranging populations of felids is limited, and there is even less known about the overall health and diseases of wild felids that inhabit or utilize urban areas.
Kerry L. Nicholson, Ted H. Noon, Paul R. Krausman   +2 more
doaj   +1 more source

Selective expansion of viral variants following experimental transmission of a reconstituted feline immunodeficiency virus quasispecies [PDF]

, 2013
Following long-term infection with virus derived from the pathogenic GL8 molecular clone of feline immunodeficiency virus (FIV), a range of viral variants emerged with distinct modes of interaction with the viral receptors CD134 and CXCR4, and ...
Margaret J Hosie, Martin Kraase (276419), McMonagle Elizabeth, Kraase, M., Varela, M., Mariana Varela (81646), Kraase Martin, Nicola Logan (276420), Mariana Varela, Hosie Margaret J., Brian J Willett, Brian J. Willett (276418), Logan Nicola, Elizabeth McMonagle (276421), Willett Brian J., Hosie, M.J., Varela Mariana, Nicola Logan, Logan, N., Willett, B.J., McMonagle, E., Margaret J. Hosie (276422), Elizabeth McMonagle, Martin Kraase   +23 more
core   +1 more source

Emerging Viruses in the Felidae: Shifting Paradigms

Viruses, 2012
The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning ...
Meredith A. Brown, Jill Pecon-Slattery, Melody E. Roelke, Agostinho Antunes, Warren E. Johnson, Jennifer L. Troyer, Stephen J. O’Brien   +6 more
doaj   +1 more source

A single site for N-linked glycosylation in the envelope glycoprotein of feline immunodeficiency virus modulates the virus-receptor interaction [PDF]

, 2008
Feline immunodeficiency virus (FIV) targets helper T cells by attachment of the envelope glycoprotein (Env) to CD134, a subsequent interaction with CXCR4 then facilitating the process of viral entry.
Margaret J Hosie, Ayman Samman, Willett Brian J, Samman, Ayman, Logan Nicola, Brian J Willett, Samman Ayman, McMonagle, Elizabeth L., Hosie Margaret J, Logan, Nicola, McMonagle Elizabeth L, Nicola Logan, Hosie, Margaret J., Willett, Brian J., Elizabeth L McMonagle   +14 more
core   +1 more source