Results 81 to 90 of about 7,034 (210)

In vitro hepatic metabolism of mefloquine using microsomes from cats, dogs and the common brush-tailed possum (Trichosurus vulpecula).

PLoS ONE, 2020
Feline infectious peritonitis (FIP) is a systemic, fatal, viral-induced, immune-mediated disease of cats caused by feline infectious peritonitis virus (FIPV). Mefloquine, a human anti-malarial agent, has been shown to inhibit FIPV in vitro.
Aaron Michael Izes, Benjamin Kimble, Jacqueline Marie Norris, Merran Govendir   +3 more
doaj   +1 more source

A Focus On Coronaviruses Infections In Animals: Review Article

Journal of Applied Veterinary Sciences, 2020
Coronaviruses are large, enveloped and single-stranded, non-segmented with positive sense RNA virus belong to Nidovirus, family Coronavirirdae and included two subfamilies Orthocoronavirinae and Letovirinae. There are four genera variable in antigenestic
Shahbaa K. AL-Taee, Hana Kh.Ismail, Al-Saidya A. M. , Al-sabaawy, H.B.   +3 more
doaj   +1 more source

Colangiocarcinoma hepático en un felino y hallazgos anatomopatólogicos, y clínicos compatibles con peritonitis infecciosa felina [PDF]

, 2012
Se presentan los hallazgos patomorfológicos de colangiocarcinoma hepático (CGC) con efusión peritoneal en un gato doméstico geronte y se relaciona con la sintomatología clínica y los hallazgos anatomopatológicos compatibles con la peritonitis infecciosa ...
AI Roque, JA Daza H., Julieta Ochoa A.
core   +3 more sources

Structure‐Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus‐2 Nsp3 Macrodomain

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Robin Krishnathas, Konstantin S. Mineev, Nikolaos K. Fourkiotis, Franck Touret, Christos Sideras‐Bisdekis, Aikaterini C. Tsika, Santosh Lakshmi Gande, Verena Linhard, Sridhar Sreeramulu, Frank Lennartz, Manfred S. Weiss, Bruno Coutard, Georgios A. Spyroulias, Harald Schwalbe   +13 more
wiley   +1 more source

Clinical reasoning in feline epilepsy: Which combination of clinical information is useful? [PDF]

, 2017
We sought to identify the association between clinical risk factors and the diagnosis of idiopathic epilepsy (IE) or structural epilepsy (SE) in cats, using statistical models to identify combinations of discrete parameters from the patient signalment ...
Packer, R M A, Pakozdy, A, Solcan, G, Stanciu, G D, Volk, H A   +4 more
core   +2 more sources

Exploring Nirmatrelvir Derivatives Through P2 Substituent Modifications and Warhead Innovations Targeting the Main Protease of SARS‐CoV‐2

Archiv der Pharmazie, Volume 358, Issue 11, November 2025.
This study explores structural tuning of SARS‐CoV‐2 Mpro inhibitors through P2 position substitutions and novel warheads. Combining computational modeling and biochemical assays, we found that hydrophobic π‐rich groups and uncommon warheads like fluoro‐vinylsulfone or nitrile enhance potency.
Felipe Cardoso Prado Martins, Johannes Lang, Fernanda dos Reis Rocho, Xianxian Wang, Vinícius Bonatto, Jerônimo Lameira, Christian Klein, Carlos Alberto Montanari   +7 more
wiley   +1 more source

Immunocytochemical demonstration of feline infectious peritonitis virus within cerebrospinal fluid macrophages

Journal of Feline Medicine and Surgery, 2013
A 4-month-old female entire domestic shorthair cat presented with an acute onset of blindness, tetraparesis and subsequent generalised seizure activity. Haematology and serum biochemistry demonstrated a moderate, poorly regenerative anaemia, hypoalbuminaemia and hyperglobulinaemia with a low albumin:globulin ratio.
Edward J, Ives, An E, Vanhaesebrouck, Francesco, Cian   +2 more
openaire   +2 more sources

Porcine epidemic diarrhea virus (CV 777) and feline infectious peritonitis virus (FIPV) are antigenically related [PDF]

Archives of Virology, 1988
Using gut sections from pigs infected with porcine epidemic diarrhea virus (strain CV 777) and ascitic fluid from cats which had succumbed to feline infectious peritonitis (FIP), a weak cross reaction was found by immunofluorescence. Its specificity was confirmed when detergent-treated purified CV 777 showed a prominent reaction with FIPV antibodies in
Horzinek, M.C., Zhou Yaling, Ederveen, J., Egberink, H.F., Pensaert, M.   +4 more
openaire   +3 more sources

Acute onset neurological deficits and hypocalcaemia associated with nutritional secondary hyperparathyroidism in three juvenile servals (Leptailurus serval)

Australian Veterinary Journal, Volume 103, Issue 11, Page 767-774, November 2025.
Nutritional secondary hyperparathyroidism is a metabolic disorder caused by an imbalance in calcium homeostasis and is typically associated with the feeding of a calcium‐deficient diet. Nutritional secondary hyperparathyroidism has been reported in domestic species, including cats and dogs, as well as captive carnivores and wildlife including lions ...
JL Austen, JW Wheelahan, J O'Dwyer, S Beths, NL Rourke, BR Gardner   +5 more
wiley   +1 more source

Humoral Immune Responses of Cats to Feline Infectious Peritonitis Virus Infection.

Journal of Veterinary Medical Science, 1992
Immunoperoxidase antibody (IPA) method as a titrating method of feline infectious peritonitis (FIP) virus (FIPV) was developed for titrating antibody to FIPV (IPA-titer). By this method the immune responses of the cats that had been infected with FIPV, were traced. The infected cats could be grouped into three types by their immune response to FIPV and
K, Kai, M, Yukimune, T, Murata, Y, Uzuka, M, Kanoe, H, Matsumoto   +5 more
openaire   +3 more sources