Results 1 to 10 of about 2,244 (118)

A Natural Peptide from the American Cockroach Suppresses Feline Infectious Peritonitis Virus [PDF]

Biology
Feline infectious peritonitis virus (FIPV) causes a fatal and immune-mediated disease in cats with limited treatment options. Natural products offer promising antiviral candidates, but animal-derived peptides remain underexplored.
Tengyu Zhu, Jinfeng Hou, Tong Jing, Yibo Wu, Rui Meng, Ruobing Liu, Kun Yuan, Sunchengai Cao, Xinyan Yang, Jiayi Wang, Ziyin Wang, Zhengyan Zhu, Yaogui Sun, Lin Jin   +13 more
doaj   +2 more sources

Glycyrrhiza polysaccharide inhibits feline infectious peritonitis virus infection screened by a recombinant virus expressing eGFP protein [PDF]

BMC Veterinary Research
Background Feline infectious peritonitis (FIP) is a fatal infectious disease caused by feline infectious peritonitis virus (FIPV) which causes death of young cats less than 2 years old. Until now, few drugs are available for treatment of FIP.
Yuan Yang, Haixia Fu, Mengyu Chang, Mengjia Zhang, Jiaru Zhou, Kangkai Xu, Mingjun Yang, Wentao Li, Hongmei Zhu   +8 more
doaj   +2 more sources

Structure and receptor recognition of type-II feline infectious peritonitis virus spike glycoprotein [PDF]

The EMBO Journal
Type-II feline infectious peritonitis virus (FIPV-II) is a lethal alphacoronavirus, whose high homology with the human coronavirus CCoV-HuPn-2018 carries the risk of potential zoonotic FIPV-II transmission to humans.
Sheng Niu, Yuyang Tian, Linh Nguyen, Chongzhi Bai, Xiaohan Hou, Dan Wang, Ziqian Niu, Zhimin Liu, Jianle Ren, Wentao Li, Qihui Wang, Wen-xia Tian, Junqing Sun, George Fu Gao   +13 more
doaj   +2 more sources

Ursodeoxycholic acid inhibits feline infectious peritonitis virus infection through activating JAK-STAT signaling pathway-induced type I interferon [PDF]

Microbiology Spectrum
Feline infectious peritonitis virus (FIPV), a highly pathogenic subtype of feline coronavirus, is characterized by antigenic variability and immune evasion, resulting in limited efficacy of existing clinical therapeutic regimens.
Yi Zhong, Zhiwei Sun, Ziyan Song, Jinman Ding, Yanwen Song, Yi Li, Guisong Liao, Xin Wang, Yan Zeng, Nan Hu, Xingcui Zhang, Zhenhui Song   +11 more
doaj   +2 more sources

A feline coronavirus nucleocapsid protein disrupts ZC3HAV1-viral RNA association to counteract host RNA-level restriction. [PDF]

PLoS Pathogens
BackgroundCoronaviruses have evolved intricate mechanisms to evade host RNA surveillance systems and sustain efficient replication. The feline infectious peritonitis virus (FIPV), a highly lethal feline coronavirus that causes systemic vasculitis and ...
Miao Zhang, Na Li, Kelimujiang Aishanjiang, Aoxing Tang, Meng Zhu, Shiqiang Zhu, Da Zhang, Lingxue Yu, Jie Zhu, Chuanfeng Li, Chunchun Meng, Yingqi Zhu, Guoxin Li, Guangqing Liu   +13 more
doaj   +2 more sources

Serotype I and II Feline Coronavirus Replication and Gene Expression Patterns of Feline Cells—Building a Better Understanding of Serotype I FIPV Biology

Viruses, 2022
Feline infectious peritonitis (FIP) is a disease of domestic cats caused by the genetic variant of the feline coronavirus (FCoV) and feline infectious peritonitis virus (FIPV), currently grouped into two serotypes, I and II.
Sarah Cook, Brian G Murphy, Christine Haake   +2 more
exaly   +3 more sources

Imipramine inhibits feline infectious peritonitis virus infection by targeting host cholesterol metabolism via NPC1 [PDF]

Antimicrobial Agents and Chemotherapy
Feline infectious peritonitis (FIP), a fatal disease caused by FIP virus (FIPV), currently lacks effective vaccines and treatments. Imipramine, a tricyclic antidepressant with known broad-spectrum antiviral properties, was investigated for its efficacy ...
Rui Jing, Yao Yao, Yuhan Li, Shuo Zheng, Hongxuan Li, Li Kang, Li Gao, Pinghuang Liu   +7 more
doaj   +2 more sources

The ORF1ab of Feline Coronavirus Plays a Critical Role in Regulating the Innate Immune Response [PDF]

Viruses
Feline coronaviruses (FCoVs) are divided into two groups: feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV). FIPV is responsible for the severe disease known as feline infectious peritonitis, while FECV typically causes ...
Haorong Gu, Chuqiao Xia, Hongtao Kang, Honglin Jia   +3 more
doaj   +2 more sources

Identification of potential inhibitors of the main protease from feline infectious peritonitis virus using molecular docking and dynamic simulation approaches [PDF]

PeerJ
Background Feline infectious peritonitis virus (FIPV) is one of cats’ most serious viral infections. The FIPV infection induces a complicated syndrome in the affected cats, including immunosuppression and severe inflammatory conditions.
Mohd Yasir Khan, Abid Ullah Shah, Nithyadevi Duraisamy, Nadine Moawad, Reda Nacif ElAlaoui, Mohammed Cherkaoui, Maged Gomaa Hemida   +6 more
doaj   +3 more sources

Antiviral and Immunomodulatory Effects of α-Mangostin Against Feline Infectious Peritonitis Virus: In Vitro Assay [PDF]

Animals
Feline infectious peritonitis virus (FIPV), caused by a mutated form of feline coronavirus, poses a significant threat to feline health worldwide, with limited therapeutic options available. This study investigated the antiviral potential of α-mangostin (
Varanya Lueangaramkul, Pratipa Termthongthot, Natjira Mana, Pharkphoom Panichayupakaranant, Ploypailin Semkum, Porntippa Lekcharoensuk, Sirin Theerawatanasirikul   +6 more
doaj   +2 more sources