Results 91 to 100 of about 4,744,816 (317)
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Olha Khoptiana,1 Valentyn Svintsitskyi,1 Sergiy Nespryadko,1 Natalia P Tsip,1 Teimuraz Gogisvanidze,2 Mikheil Dzimistarishvili,2 Dmytro Krasylenko,2 Mykhailo Serhiiovych Chetverikov,3 Igor Pavlovych Nigutsa,3,4 Dmytro Sumtsov,4 Pavlo Dolyk5 1Scientific ...
Khoptiana O +10 more
doaj
Objective To investigate the changes in bile acid (BA) metabolites within the follicular fluid (FF) of patients with diminished ovarian reserve (DOR) and to identify novel diagnostic markers that could facilitate early detection and intervention in DOR ...
Shu Ding +10 more
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Effects of Different Caffeine Dosages on Maximal Physical Performance and Potential Side Effects in Low-Consumer Female Athletes: Morning vs. Evening Administration [PDF]
Houda Bougrine +7 more
openalex +1 more source
Painful coitus often prevents sexual satisfaction. The symptom of dyspareunia presents special propblems for the patient and for the doctor. A family physician with sexual knowledge, self-awareness, and time to carefully counsel and examine the patient can adequately manage many patients with this complaint.Dealing with painful intercourse can be ...
openaire +3 more sources
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source

