Results 61 to 70 of about 12,275,099 (398)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Successful Treatment of Obstructive Oligospermia/Azoospermia Due to Mullerian Duct Cyst by Transurethral Resection: A Case Report [PDF]
International Journal of Fertility and Sterility, 2007 Cystic lesions in midline of prostate are uncommon and considered as congenital disorders. Here we report a 33- year- old male who presented with either azoospermia or decreased ejaculate volume leading to infertility and for whom performing Transrectal ...
Ahmad Vosough +4 more
doaj +1 more source
Divided Consciousness And Female Companionship: Reconstructing Female Subjectivity On Greek Vases [PDF]
, 1997 Art ...
Petersen, Lauren H.
core +1 more source
Historia Mathematica, 1980 AbstractWhat was the extent of women's interest in and practice of mathematics in Britain in the 18th century? The evidence from the Ladies' Diary, recently given by T. Perl (Historia Mathematica 6 (1979), 36–53), is extended, and other sources of information, particularly subscription lists, are discussed.
Wallis, Ruth, Wallis, Peter
openaire +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Cardiovascular Disease and the Female Disadvantage
International Journal of Environmental Research and Public Health, 2019 Age-standardised rates of cardiovascular disease (CVD) are substantially higher in men than women. This explains why CVD has traditionally been seen as a “man’s problem”.
M. Woodward
semanticscholar +1 more source
Particle and Fibre ToxicologyBackground With rapid increase in the global use of various plastics, microplastics (MPs) and nanoplastics (NPs) pollution and their adverse health effects have attracted global attention.
Shukun Wan +9 more
doaj +1 more source
Reading Female Readers: The Female Quixote And Female Quixotism
, 2011 These two novels offer clues to the idea of the reader and to the understanding of the nature of the reading act in the eighteenth-century context. Because they take the fiction they read as models of the world, both protagonists violate emerging rules for reading fiction.
openaire +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source