Results 51 to 60 of about 412,843 (303)

Valgus Impacted Femoral Neck Fractures: Surgery or Non-Operative Approach?

Journal of Orthopedic and Spine Trauma, 2021
Background: Non-operative management of valgus impacted femoral neck fracture leads to prolonged bed rest which may lead to deep vein thrombosis. The preferred method is the internal fixation because of pain control, enhanced mobilization, and better ...
Arvin Najafi, Mohsen Tavakoli, Danoosh Zargar, Dorsa Hadavi, Ehsan Seif, Salman Azarsina   +5 more
doaj   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Unstable Pelvic Fractures Associated with Femoral Shaft Fractures: A Retrospective Analysis

Biomedical Journal, 2013
Background: Both pelvic fractures and femoral shaft fractures are caused by high-energy injuries. When unstable pelvic fractures and femoral shaft fractures occur concomitantly, the optimal treatment method is controversial.
Chun-Liang Wu, I-Chuan Tseng, Jau-Wen Huang, Yi-Hsun Yu, Chun-Yi Su, Chi-Chuan Wu   +5 more
doaj  

Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA.

PLoS ONE, 2019
The present study aimed to investigate the prevalence and clinical consequences of occult intra-operative periprosthetic femoral fractures in total hip arthroplasty (THA). Between 2012 and 2017, a total of 113 primary THAs were enrolled.
Ho Hyun Yun, Jung Taek Lim, Se-Hyun Yang, Phil Sun Park   +3 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Prevalent morphometric vertebral fractures in professional male rugby players. [PDF]

, 2014
There is an ongoing concern about the risk of injury to the spine in professional rugby players. The objective of this study was to investigate the prevalence of vertebral fracture using vertebral fracture assessment (VFA) dual energy X-ray ...
Beck, B., Hind, K., Birrell, F., Birrell, Fraser, Birrell Fraser, Hind, K, Belinda Beck, Beck, Belinda, Fraser Birrell, Hind Karen, Hind, Karen, Beck Belinda, Karen Hind, Beck, B, Birrell, F   +14 more
core   +1 more source

The Relationship between the Lee Score and Postoperative Mortality in Patients with Proximal Femur Fractures

Revista Brasileira de Ortopedia
Objective To verify the predictive value of the Lee score for mortality in a one-year period after proximal femur fracture surgery. The present study also evaluated the isolated predictive capacity of other variables.
Marcelo Teodoro Ezequiel Guerra, Luiz Giglio, João Mauro Mendina Morais, Giovanna Labatut, Monica Cavanus Feijó, Carlos Eduardo Peixoto Kayser   +5 more
doaj   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Hip geometry and femoral neck fractures: A meta-analysis

Journal of Orthopaedic Translation, 2018
Background: Several studies have reported hip geometry to predict the femoral neck fractures. However, they showed inconsistency. Objectives: To determine the association between hip geometry and femoral neck fractures. Methods: Published literature from
Jonny Karunia Fajar, Taufan Taufan, Muhammad Syarif, Azharuddin Azharuddin   +3 more
doaj   +1 more source

A three-dimensional measurement study of fracture displacement in Garden I femoral neck fracture: a retrospective study

BMC Musculoskeletal Disorders, 2023
Background Garden I femoral neck fractures are nondisplaced femoral neck fractures. Nonoperative treatment and in situ fixation are the preferred treatments.
Ying Wang, Jianxiong Ma, Haohao Bai, Hongqi Zhan, Bin Lu, Lei Sun, Hongzhen Jin, Xingwen Zhao, Yanfei Wu, Jiahui Chen, Xinlong Ma   +10 more
doaj   +1 more source