Results 51 to 60 of about 86,807 (268)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

Advanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao, Hai‐Jin Zeng, Zun Wang, Chun‐Gu Hong, Yi‐Juan Tan, Yan‐Xin Duan, Jing‐Yao Luo, Ming‐Jie Luo, Yi‐Wei Liu, Xin Wang, Yi Luo, Teng‐Fei Wan, Yong Zhou, Zheng‐Guang Wang, Guo‐Wen Hu, Hao Yin, Xin‐Yue Hu, Zhen‐Xing Wang, Ze‐Hui He, Si‐Yi Cheng, Wei Du, Zhe Guan, Hai‐Li Lang, Hong‐Ji Liu, Jia Cao, Peng Chen, Jiang‐Hua Liu, Hui Xie, Chun‐Yuan Chen   +28 more
wiley   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Treatment of established osteoporosis: a systematic review and cost–utility analysis [PDF]

, 2002
Background and aims Osteoporosis is a systemic skeletal disease, characterised by low bone mass and microarchitectural deterioration of bone tissue with a subsequent increase in bone fragility and susceptibility to fracture.
J. E. Brazier, Stevenson, M., N.W. Calvert, J.A. Kanis, Kanis, JA, Stevenson, M, Calvert, N.W., Calvert, NW, M. Lloyd Jones, Brazier, JE, Lloyd Jones, M, Kanis, J.A., M. Stevenson, Brazier, J.E., Lloyd Jones, M., Calvert, N.   +15 more
core   +1 more source

Changes in the anatomical position of the superficial and deep femoral arteries during internal fixation of intertrochanteric fractures

, 2022
Introduction Fixation for intertrochanteric proximal femoral fractures are increasing globally, one of the risks with surgical treatment is injury to the deep and superficial femoral arteries (DFA and SFA, respectively).
Coughlan, A, Nusem, I, Ng, SK
core   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

The Warwick Hip Trauma Evaluation – an abridged protocol for the WHiTE Study : a multiple embedded randomised controlled trial cohort study [PDF]

, 2012
Fractures of the proximal femur are one of the greatest challenges facing the medical community, constituting a heavy socioeconomic burden worldwide. The National Hip Fracture Audit currently provides a framework for service evaluation.
Griffin, Xavier L., Costa, Matthew L., Costa, ML, Parsons, Nicholas R., Boardman, F, Parsons, N, Griffiths, F, Achten, Juul, Boardman, Felicity K., Griffiths, Frances, Griffin, XL, Achten, J   +11 more
core   +1 more source

Bamboo‐Like Whiskers‐Reinforced Bioceramics Accelerate Large Segmental Bone Regeneration via Dual Modulation of Type‐H Vessels and Osteoinduction

Advanced Science, EarlyView.
The graphical abstract image of bamboo‐like whisker‐reinforced Ca‐P bioceramics accelerating large segmental bone regeneration. ABSTRACT Regenerative repair of segmental bone defect remains a major clinical challenge. The conventional mental implants suffer from mechanical strength mismatch and long‐term foreign bodies presence.
Cong Feng, Haibo Teng, Chuyao Xu, Jiaze He, Keting Liu, Xueying Li, Kai Zhang, Xiangdong Zhu, Xiangfeng Li, Jianguo Xu, Xingdong Zhang   +10 more
wiley   +1 more source

Femoral Neck Fracture [PDF]

, 2016
History of present illness: A 74-year-old male presented to the emergency department with left hip pain after falling off his bicycle. Pain is 3/10 in severity and exacerbated by movement. Patient denied head trauma. Exam showed left hip tenderness, 3/5
Jonathan Lee, Lee, Jonathan, Toohey, Shannon, Shannon Toohey   +3 more
core   +1 more source

Lower 1-Year Postoperative Mortality After Acetabular Versus Proximal Femoral Fractures in Elderly Patients

, 2021
BACKGROUND Geriatric acetabular fractures are becoming more common due to demographic changes. Compared with proximal femoral fractures, surgical treatment is more complex and often does not allow full-weight-bearing.
Iris F. Brouze, Bastian, Johannes D., Johannes D. Bastian, Simon D. Steppacher, Joseph M. Schwab, Stetzelberger, Vera M, Brouze, Iris F, Tannast, Moritz, Schwab, Joseph M, Vera M. Stetzelberger, Steppacher, Simon D., Moritz Tannast   +11 more
core   +1 more source