Results 61 to 70 of about 412,843 (303)

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Bilateral Femoral Head Insufficiency Fractures and Multiple Vertebral Fractures: A Case Report on Rare Presentations of Pregnancy and Lactation-associated Osteoporosis and Their Outcomes

, 2020
Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition seen in the last trimester of pregnancy and early puerperal period which can result in vertebral and femoral fractures. In this case report, two cases of fractures secondary to PLO,
Selin Özen, Seyhan Sözay, Oya Ümit Yemişci   +2 more
core   +1 more source

Development and validation of a paediatric long-bone fracture classification : a prospective multicentre study in 13 European paediatric trauma centres [PDF]

, 2011
Background: The aim of this study was to develop a child-specific classification system for long bone fractures and to examine its reliability and validity on the basis of a prospective multicentre study.
Marzi, Ingo, Ralf Kraus, Lutz von Laer, Kraus, Ralf, Kaiser, Martin, Röder Christoph, von Laer Lutz, Schneidmüller, Dorien, Martin Kaiser, Dietrich, Daniel, Christoph Röder, Dietrich, Daniel J., Ingo Marzi, Kaiser Martin, Marzi Ingo, Röder, Christoph, Schneidmüller Dorien, Dietrich Daniel, von Laer, Lutz, Laer, Lutz von, Kraus Ralf, Dorien Schneidmüller, Daniel Dietrich   +22 more
core   +3 more sources

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Increased risk of intraoperative and early postoperative periprosthetic femoral fracture with uncemented stems: 7,169 total hip arthroplasties from 8 Danish centers

Acta Orthopaedica, 2017
Background and purpose — The use of uncemented fixation in total hip arthroplasty (THA) is increasing. Registry studies have indicated an increased risk of revision of uncemented implants due to early periprosthetic femoral fracture.
Martin Lindberg-Larsen, Christoffer C Jørgensen, Søren Solgaard, Anne G Kjersgaard, Henrik Kehlet, On behalf of the Lundbeck Foundation Centre for Fast-Track Hip and Knee Replacement Collaborative Group   +5 more
doaj   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Bio-mechanical effects of femoral neck system versus cannulated screws on treating young patients with Pauwels type III femoral neck fractures: a finite element analysis

BMC Musculoskeletal Disorders
Introduction As a novel internal fixation for femoral neck fractures, the femoral neck system has some advantages for young Pauwels type III femoral neck fractures without clear biomechanical effects and mechanisms. Thus, the objection of the study is to
Xiao Fan, Yimin Zhou, Shiyou Dai, Kecheng Lao, Qiliang Zhang, Tengbo Yu   +5 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Femoral osteochondroplasty can be performed effectively without the risk of avascular necrosis or femoral neck fractures in an experimental ovine FAI model. [PDF]

, 2018
OBJECTIVE The experimental induction of cam-type femoroacetabular impingement (FAI) in sheep is established. To tap the full potential of this ovine model, one should be able to perform a femoral osteochondroplasty safely.
N. Wolfer, B. von Rechenberg, H.E. Dawson, Nuss, K, L. Arendt, P.R. Kircher, Arendt, L, Tannast, Moritz, Wolfer, N, M. Tannast, T.D. Lerch, Schmaranzer, Florian, F. Schmaranzer, Lerch, Till, Steppacher, Simon Damian, Dawson, Heather, Kircher, PR, von Rechenberg, B, S.D. Steppacher, K. Nuss   +19 more
core   +1 more source

Ipsilateral femoral neck and shaft fractures [PDF]

The Egyptian Orthopaedic Journal, 2014
BackgroundIpsilateral, concomitant femoral neck and shaft fracture is a rare fracture pattern that presents a diagnostic and treatment challenge.Patients and methodsFive cases treated with the Russell-Taylor reconstructive nail between 1999 and 2005 at ...
Fathy Salama, Mohamed Abdel-Kader, Osman Mohamed   +2 more
doaj   +1 more source