Results 71 to 80 of about 1,575,992 (358)

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

The Relationship between the Lee Score and Postoperative Mortality in Patients with Proximal Femur Fractures

Revista Brasileira de Ortopedia
Objective To verify the predictive value of the Lee score for mortality in a one-year period after proximal femur fracture surgery. The present study also evaluated the isolated predictive capacity of other variables.
Marcelo Teodoro Ezequiel Guerra, Luiz Giglio, João Mauro Mendina Morais, Giovanna Labatut, Monica Cavanus Feijó, Carlos Eduardo Peixoto Kayser   +5 more
doaj   +1 more source

Mechanical Competence and Bone Quality Develop During Skeletal Growth. [PDF]

, 2019
Bone fracture risk is influenced by bone quality, which encompasses bone's composition as well as its multiscale organization and architecture. Aging and disease deteriorate bone quality, leading to reduced mechanical properties and higher fracture ...
Amling, Michael, Busse, Björn, Chushkin, Yuriy, Gludovatz, Bernd, Püschel, Klaus, Riedel, Christoph, Ritchie, Robert O, Schaible, Eric, Schmidt, Felix N, Stockhausen, Kilian E, Vettorazzi, Eik, Zimmermann, Elizabeth A, Zontone, Federico   +12 more
core   +1 more source

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, EarlyView.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Unstable Pelvic Fractures Associated with Femoral Shaft Fractures: A Retrospective Analysis

Biomedical Journal, 2013
Background: Both pelvic fractures and femoral shaft fractures are caused by high-energy injuries. When unstable pelvic fractures and femoral shaft fractures occur concomitantly, the optimal treatment method is controversial.
Chun-Liang Wu, I-Chuan Tseng, Jau-Wen Huang, Yi-Hsun Yu, Chun-Yi Su, Chi-Chuan Wu   +5 more
doaj  

Increased risk of intraoperative and early postoperative periprosthetic femoral fracture with uncemented stems: 7,169 total hip arthroplasties from 8 Danish centers

Acta Orthopaedica, 2017
Background and purpose — The use of uncemented fixation in total hip arthroplasty (THA) is increasing. Registry studies have indicated an increased risk of revision of uncemented implants due to early periprosthetic femoral fracture.
Martin Lindberg-Larsen, Christoffer C Jørgensen, Søren Solgaard, Anne G Kjersgaard, Henrik Kehlet, On behalf of the Lundbeck Foundation Centre for Fast-Track Hip and Knee Replacement Collaborative Group   +5 more
doaj   +1 more source

Dual-mobility socket in challenging total hip arthroplasty : 2-6 years follow-up. [PDF]

, 2018
The success of dual-mobility sockets in achieving implant stability in primary hip replacement is already well established. However, stability cannot always be achieved, especially when dealing with more difficult indications.
Audenaert, Emmanuel, Pattyn, Christophe, Willekens, Philippe   +2 more
core   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Influence of associated femoral head fractures on surgical outcomes following osteosynthesis in posterior wall acetabular fractures

BMC Musculoskeletal Disorders, 2022
Background To date, no study has compared the surgical outcomes between posterior wall acetabular fractures with and without associated femoral head fractures. Therefore, we evaluated whether an associated femoral head fracture increases the incidence of
Po-Ju Lai, Chih-Yang Lai, I-Chuan Tseng, Chun-Yi Su, Yi-Hsun Yu   +4 more
doaj   +1 more source