Results 101 to 110 of about 1,930,858 (393)

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Femoroacetabular Impingement (FAI) Syndrome : the medical imaging perspective [PDF]

, 2014
Introduction: Sports persons, physicians, orthopods and radiologists have become increasingly aware of the extra stress that is imposed on the hip joints with excessive activity particularly when superadded weight bearing and asymmetrical variations from
Zammit, Anthony
core  

Recent origin of low trabecular bone density in modern humans [PDF]

, 2014
Humans are unique, compared with our closest living relatives (chimpanzees) and early fossil hominins, in having an enlarged body size and lower limb joint surfaces in combination with a relatively gracile skeleton (i.e., lower bone mass for our body ...
Bernhard Zipfel, Brian G. Richmond, Christopher B. Ruff, Cowgill, Eaton, Habiba Chirchir, Jean-Jacques Hublin, Kristian J. Carlson, Ruff, Ruff, Tracy L. Kivell, Trinkaus   +11 more
core   +1 more source

Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration

Advanced Science, EarlyView.
A dynamic fibrous hydrogel (DFH) is developed by covalent crosslinking of gelatin with tea‐derived trichomes, which integrates the structural and compositional fidelity of native extracellular matrix with photothermal and oxidative responsiveness, introducing a novel “stem cell recruits stem cell” strategy that orchestrates co‐homing of endogenous and ...
Jianmei Chen, Meiling Su, Xinyu Wu, Hongyu Wu, Haotian Wu, Pinghu Zhang, Xueying An, Zongguang Liu   +7 more
wiley   +1 more source

The ratio between the screw distance and femoral neck width on lateral radiography is a reliable predictor of femoral head necrosis: a clinical review and corresponding numerical simulations

Journal of Orthopaedic Surgery and Research
Background Fixation instability serves as an initial trigger for femoral head necrosis in patients with femoral neck fractures undergoing internal fixation. The configuration of screw trajectories is critical in determining the stability of the fixation.
Hong Li, Shengyu Wan, Jian Zhang, Fan Wu, Xiaozhong Luo, Chao Wu, Xu Lin, Jingchi Li   +7 more
doaj   +1 more source

Long-term outcome after traumatic anterior dislocation of the hip [PDF]

, 2018
Introduction: Traumatic anterior dislocation of the hip joint is rare. Additional injuries to the hip due to dislocation are even more infrequent. Outcome is limited by osteoarthritic joint degeneration or the occurrence of avascular necrosis of the ...
Bastian, Johannes, Keel, M., Siebenrock, K., Turina, M.   +3 more
core  

Steroid induced osteonecrosis: An analysis of steroid dosing risk. [PDF]

, 2010
Osteonecrosis is a serious condition involving bone destruction that frequently requires surgical treatment to rebuild the joint. While there is an abundance of literature documenting corticosteroid related osteonecrosis, there is no consensus as to the ...
Chang, Christopher, Cheema, Gurtej, Gershwin, M Eric, Naguwa, Stanley M, Powell, Christian   +4 more
core   +1 more source

Steap4 Promotes Senile Osteoporosis via Fe2+‐ROS/C/EBPβ Feedback‐Driven Ferroptosis and Adipogenesis in Senescent BMSCs

Advanced Science, EarlyView.
Senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)‐dependent metalloreductase that reduces Fe3+ to Fe2+.
Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang   +9 more
wiley   +1 more source

Increasing the angle between caudal screw and the transverse plane may aggravate the risk of femoral head necrosis by deteriorating the fixation stability in patients with femoral neck fracture

European Journal of Medical Research
Necrosis of the femoral head is the main complication in femoral neck fracture patients with triangle cannulated screw fixation. Instant postoperative fixation instability is a main reason for the higher risk of femoral head necrosis.
Jian Zhang, Shengyu Wan, Xiaozhong Luo, Caidong Zhang, Chao Wu, Lipeng He, Jingchi Li   +6 more
doaj   +1 more source

Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head

Journal of Orthopaedic Translation
Objective: To investigate the characteristics of three-dimensional distribution of subchondral fracture lines on the surface of the osteonecrosis femoral head, and to discuss the underlying mechanisms that contribute to its collapse.
Yan-Bin Wu, Guang-Bo Liu, Huo Li, Jia-Zhou Wu, Jin-Shu Tang, Jian-Ting Ye, Ying-Jie Xiong, Xi-Wei Peng, Ze-Xian Liu, Yu-Zheng Lu, Cong-Cong Guan, Hao-Ye Meng, Xiao-Han Sun, Xin Wang, Ai-Yuan Wang, Zhe Zhao, Yuan Hu, Yu-Feng Liu, Li-Jun Sun, Ling Qin, Jiang Peng   +20 more
doaj   +1 more source