Results 71 to 80 of about 24,753 (186)

Mendelian randomization analysis identifies HLA‐A and AP2M1 as genetic biomarkers linked to immune–endocytic crosstalk in intervertebral disc degeneration

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
HLA‐A and AP2M1 are identified as key endocytosis‐related biomarkers that modulate immune–endocytic crosstalk via mTOR signaling to regulate cell survival, immune infiltration, and the progression of intervertebral disc degeneration. Abstract Intervertebral disc degeneration (IVDD) is a major contributor to chronic spinal disorders, yet the role of ...
Yukui Tian, Xue Bai, Nianrong Han, Cheng Wang, Junchang Liu   +4 more
wiley   +1 more source

Translational Pathways for Smart and Bioactive Dental Biomaterials: Biocompatibility Standards, Sterilisation, Sustainability and Regulation

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
Smart and bioactive dental biomaterials can do more than replace tissue, but getting them into the clinic requires more than promising lab results. This review brings together practical requirements for translation, covering ISO‐based biocompatibility planning, low‐temperature sterilisation for sensitive materials, life‐cycle assessment for ...
Katarzyna Chojnacka, Marcin Mikulewicz
wiley   +1 more source

Cerebral in situ ischemic postconditioning: From bench to bedside and beyond

Neuroprotection, Volume 4, Issue 1, Page 48-64, March 2026.
This review explores the translational potential of in situ ischemic postconditioning in acute ischemic stroke. Preclinical and clinical evidence is summarized to highlight its promise as a neuroprotective strategy in the era of endovascular therapy.
Xiao Jiang, Wenbo Zhao, Yongbo Xu, Fanlei Meng, Ming Wei   +4 more
wiley   +1 more source

Core Decompression Augmented With Autologous Bone Marrow Aspiration Concentrate for Early Avascular Necrosis of the Femoral Head

Arthroscopy Techniques, 2016
Lack of necessary perfusion to the femoral head can lead to necrosis of the underlying bone (avascular necrosis) and result in femoral and acetabular surface changes in advanced stages.
Lucas Arbeloa-Gutierrez, M.D., Chase S. Dean, M.D., Jorge Chahla, M.D., Cecilia Pascual-Garrido, M.D.   +3 more
doaj   +1 more source

Femoral Neck System Versus Total Hip Arthroplasty in the Treatment of Pauwels Type III Unstable Femoral Neck Fractures in Patients Aged 60–70 Years: A Comparative Analysis of Clinical Efficacy and Hip Function

Orthopaedic Surgery, Volume 18, Issue 3, Page 402-411, March 2026.
Graphical abstract of the comparative study between FNS and THA for Pauwels type III unstable femoral neck fractures in patients aged 60–70 years. The diagram outlines the study population, key perioperative outcomes (operation duration, blood loss), dynamic changes in hip function (Harris Hip Score) over 12 months of follow‐up, and personalized ...
Xiangyu Zong, Kuishuai Xu, Xuechao Yu, Xinyu Cui, Yanling Hu, Yingze Zhang, Tianrui Wang   +6 more
wiley   +1 more source

Experimental analysis of femoral head intraosseous vascular anastomosis in the treatment of porcine subcapital femoral neck fractures

Heliyon
Introduction: Femoral neck fractures are challenging injuries associated with a compromised blood supply to the femoral head, leading to a high risk of avascular necrosis and poor clinical outcomes. This study aimed to investigate the efficacy of femoral
Wei Deng, Jiaming Wan, Dingsong Wang, Kailong Geng, Guangliang Zhang, Ruixing Hou   +5 more
doaj   +1 more source

Femoral Neck Fracture With Anterior Tilt

Orthopaedic Surgery, Volume 18, Issue 3, Page 558-568, March 2026.
In patients with OTA/AO type 31B femoral neck fractures, anterior tilt fractures were more common among females and those with valgus malalignment. Although outcomes and complication rates did not differ significantly among fracture patterns, patients with displaced fractures had a higher risk of developing femoral neck necrosis.
Yu‐Kai Wang, Ming‐Yong Chen, Yi Zhu, Sheng‐Hui Wu, Yu‐Yi Zhang, Jun Zhang, Ming Ni, Jiong Mei   +7 more
wiley   +1 more source

Perioperative Factors Associated With Allogeneic Blood Transfusion in Elective THA

Orthopaedic Surgery, Volume 18, Issue 3, Page 576-586, March 2026.
Early postoperative hematocrit is the strongest and most clinically useful predictor of transfusion risk after primary THA, while cup inclination has minimal discriminative value. A hematocrit threshold of < 0.28 L/L reliably identifies high‐risk patients and should guide transfusion‐related decision‐making.
Nikolai Ramadanov, Dakota Fuchs, Maximilian Heinz, Robert Prill, Roland Becker   +4 more
wiley   +1 more source

Three-dimensional distribution of subchondral fracture lines in osteonecrosis of the femoral head

Journal of Orthopaedic Translation
Objective: To investigate the characteristics of three-dimensional distribution of subchondral fracture lines on the surface of the osteonecrosis femoral head, and to discuss the underlying mechanisms that contribute to its collapse.
Yan-Bin Wu, Guang-Bo Liu, Huo Li, Jia-Zhou Wu, Jin-Shu Tang, Jian-Ting Ye, Ying-Jie Xiong, Xi-Wei Peng, Ze-Xian Liu, Yu-Zheng Lu, Cong-Cong Guan, Hao-Ye Meng, Xiao-Han Sun, Xin Wang, Ai-Yuan Wang, Zhe Zhao, Yuan Hu, Yu-Feng Liu, Li-Jun Sun, Ling Qin, Jiang Peng   +20 more
doaj   +1 more source

Stem cell treatment for avascular necrosis of the femoral head: current perspectives

Stem Cells and Cloning: Advances and Applications, 2014
Matthew T Houdek,1 Cody C Wyles,2 John R Martin,1 Rafael J Sierra11Department of Orthopedic Surgery, 2School of Medicine, Mayo Clinic, Rochester, MN, USAAbstract: Avascular necrosis (AVN) of the femoral head is a progressive disease that predominantly ...
Houdek MT, Wyles CC, Martin JR, Sierra RJ   +3 more
doaj