Results 121 to 130 of about 248,688 (308)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

open access: yesAdvanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang   +6 more
wiley   +1 more source

Femur Boyun Geometrisinin Femur ve Pelvis Üzerindeki Gerilme Dağılımına Etkisi [PDF]

open access: yes, 2013
Aim: In this study the effect of femoral neck geometry deformities for stress distribution onfemur and pelvis were analyzed. In this study, the stress distribution on femoral diaphysis dueto body weight was investigated in lower extremity deformities ...
Özkan, Arif, Atmaca, Halil
core  

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

open access: yesAdvanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao   +21 more
wiley   +1 more source

Human Femur Figure Mars [PDF]

open access: yes, 2007
Images are provided for assessing and consideration for exhibition.
Bromage, Timothy
core  

A Study of Sexual Dimorphism in Femora of Rural Population of South Tamilnadu, India [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2012
Aim: Assessment of human sex from skeletal parts is of particular importance in forensic osteology and relies heavily on up-to-date techniques to provide accurate information to medico- legal system. Hence this study was taken to assess the sex from an
UMAPATHY SEMBIAN   +4 more
doaj  

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

open access: yesAdvanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang   +6 more
wiley   +1 more source

Human Femur Figure Venus [PDF]

open access: yes, 2007
Images are provided for assessing and consideration for exhibition.
Bromage, Timothy
core  

Innovative Management of Double Segmental Femur Fracture without Fracture Table: A Case Report [PDF]

open access: yes
Introduction: Femoral fractures are undoubtedly common injuries, typically resulting from high-energy trauma in younger individuals or from bone fragility in older adults.
Nischay Kaushik   +5 more
core   +1 more source

Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis

open access: yesAdvanced Science, EarlyView.
Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao   +28 more
wiley   +1 more source

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