Results 151 to 160 of about 248,688 (308)

Which parameters control the leg movement of a walking insect?: I. Velocity control during the stance phase [PDF]

open access: yes, 1985
Cruse H. Which parameters control the leg movement of a walking insect?: I. Velocity control during the stance phase. The journal of experimental biology.
Cruse, Holk
core   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

open access: yesAdvanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li   +5 more
wiley   +1 more source

Sarcoma of Femur [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1911
openaire   +2 more sources

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

open access: yesAdvanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv   +13 more
wiley   +1 more source

Relationship Between Patient’s Age and Bone Mineral Density of Lomber Spine and Femur in Postmenopausal Women [PDF]

open access: yes, 2003
The aim of this study was to examine the relationship between patient’s age and lomber spine, hip regions(femur neck, trochanter, Ward’s triangle) bone mineral density (BMD) and T scores. A total of 85 postmenopausal women whose L2-4 T score was equal to
Rezzan Günaydın   +2 more
core  

Modelado computacional del desarrollo óseo humano en la placa de crecimiento del fémur distal Computational modeling of human bone development in the distal femoral growth plate

open access: yesRevista Cubana de Investigaciones Biomédicas, 2012
La elongación de los huesos largos se produce principalmente por la proliferación e hipertrofia de los condrocitos presentes en las placas de crecimiento.
Carlos Alberto Narváez-Tovar   +1 more
doaj  

Chondroma of the Femur [PDF]

open access: yesProceedings of the Royal Society of Medicine, 1909
openaire   +2 more sources

Wavelength‐Dependent Photobiomodulation Regulates Macrophage Polarization via Mitochondrial Dynamics and Metabolic Reprogramming

open access: yesAdvanced Science, EarlyView.
Light wavelength encodes distinct macrophage fates through mitochondrial and metabolic remodeling. Red 625 nm irradiation induces glycolysis, mitochondrial fission, and M1 polarization, whereas near‐infrared 850 nm irradiation promotes fatty acid oxidation, mitochondrial fusion, and M2 polarization.
Qiusheng Shi   +12 more
wiley   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

open access: yesAdvanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng   +17 more
wiley   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

open access: yesAdvanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li   +7 more
wiley   +1 more source

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