Results 151 to 160 of about 248,024 (308)
Advanced Science, EarlyView.ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao +12 more
wiley +1 more source
Innovative Management of Double Segmental Femur Fracture without Fracture Table: A Case Report
Introduction: Femoral fractures are undoubtedly common injuries, typically resulting from high-energy trauma in younger individuals or from bone fragility in older adults.
Nischay Kaushik +5 more
core +1 more source
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, EarlyView.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
Chondroblastoma of the Right Distal Femur Medial Condyle: A Case Report
Introduction: Chondroblastoma is a rare, benign but locally aggressive bone tumor typically affecting adolescents and young adults. It commonly arises in the epiphyseal region of long bones, particularly the distal femur.
Mohammed Tavfiq +3 more
core +1 more source
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Obstetric Neonatal Femur Fracture During Emergency Cesarean Section for Breech: A Case Report
Introduction: Neonatal Obstetric fractures are rare birth injuries that newborns sustained from trauma during delivery and birth process. Long bone fractures are common in vaginal breech deliveries.
Nadeem Akhtar Qureshi +1 more
core +1 more source
Advanced Science, EarlyView.A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu +13 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng +5 more
wiley +1 more source