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The pharmacokinetics of fenbendazole and oxfendazole in cattle
Veterinary Research Communications, 1984The pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11
A J, Ngomuo, S E, Marriner, J A, Bogan
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Safety evaluation of fenbendazole in swine
American Journal of Veterinary Research, 1983SUMMARY Thirty female pigs, average weight 32 kg, were given fenbendazole for 3 days to test the safety of the drug. Dosages of 0, 3, 9, 15, and 25 mg of active ingredient/kg of body weight were mixed with the feed. Chemical analysis, urinalysis, and hematologic, gross and microscopic pathologic, and bone marrow cytologic examinations revealed no ...
T F, Booze, F W, Oehme
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Comparative pharmacokinetics of fenbendazole in buffalo and cattle
Veterinary Research Communications, 1994Swamp buffalo (Bubalus bubalis) and Droughtmaster cattle (Bos indicus x B. taurus), fitted with gastrointestinal cannulae, were dosed intraruminally with fenbendazole at 7.5 mg/kg liveweight, together with a chromium oxide capsule and a pulse dose of NaCoEDTA, to estimate the flow dynamics of the digesta in the rumen and duodenum. The concentrations of
M R, Knox +4 more
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Fenbendazole Pharmacokinetics, Metabolism, and Potentiation in Horses
Drug Metabolism and Disposition, 2002The present study was designed to describe the pharmacokinetics and fecal excretion of fenbendazole (FBZ) and fenbendazole sulphoxide (FBZSO) and their metabolites in horses, to investigate the effects which concurrent feeding has on the absorption and pharmacokinetics of FBZ, and to determine the effect of coadministration of the metabolic inhibitor ...
Q A, McKellar +3 more
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Pharmacokinetics and metabolism of fenbendazole in channel catfish
Veterinary Research Communications, 1990Fenbendazole (FBZ) was administered intravenously (1 mg/kg) and orally (5 mg/kg) to catheterized, confined channel catfish. Blood samples were collected for 72 h, and resulting FBZ plasma concentrations were pharmacokinetically modelled. Following intravenous administration t 1/2 alpha was 0.51 h, t 1/2 beta was 16.8 h, body clearance (C1B) was 0.0598 ...
J V, Kitzman +9 more
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Toxicity investigation of fenbendazole, an anthelmintic of swine
American Journal of Veterinary Research, 1983SUMMARY The toxicity of fenbendazole, an anthelmintic for use in swine, was tested by feeding 8 growing pigs 2,000 mg of fenbendazole/kg of body weight daily for 14 days. A transient leukopenia developed on day 6, but values returned to base line on day 18, 4 days after discontinuation of dosing. Sorbitol dehydrogenase values were significantly (P <
R H, Hayes, F W, Oehme, H, Leipold
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Voltammetric determination of fenbendazole in veterinarian formulations
Journal of Pharmaceutical and Biomedical Analysis, 2002A versatile voltammetric method for quantitative determination of fenbendazole (FBZ) in commercial tablets has been proposed, where direct dissolution of tablets is carried out in 0.1 mol l(-1) tetrabutylamoniun tetrafluorborate containing dimethylformamide solutions.
de Oliveira, M. F. +1 more
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Efficacy of fenbendazole against giardiasis in dogs
American Journal of Veterinary Research, 1994Summary Efficacy of fenbendazole at 2 dosages for treating naturally acquired giardiasis in dogs was assessed. Giardia cysts were not detected in the feces of 6 of 6 group-1 dogs (as determined by use of the zinc sulfate concentration technique) after fenbendazole treatment (50 mg/kg of body weight, po, q 24 h, for 3 doses).
S C, Barr, D D, Bowman, R L, Heller
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Efficacy of fenbendazole for treatment of giardiasis in calves
American Journal of Veterinary Research, 1997Abstract Objective To determine efficacy of fenbendazole for treatment of giardiasis in calves. Animals Twenty male and 15 female Holstein calves (100 to 180 kg), naturally infected with Giardia sp. Procedure In vitro fenbendazole susceptibility and resistance development was determined for a ruminant Giardia isolate by use of an adherence assay ...
R M, O'Handley +6 more
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