Results 11 to 20 of about 640 (134)

Hearing Preservation After Segmental Semicircular Canal Destruction: A Report of Two Rare Cases. [PDF]

Clin Case Rep
ABSTRACT Semicircular canal fistulas are a complication of cholesteatomatous otitis media. In extremely rare cases, extensive destruction of the bony labyrinth may result in loss of approximately one‐third of the semicircular canal arc, often with wide exposure and partial injury to the membranous labyrinth, thereby increasing the risk of profound ...
Miwa T, Ogita H, Ueda K, Tarui A, Asai Y, Fujikawa T, Hakuba N.   +6 more
europepmc   +2 more sources

Pigment Epithelium-Derived Factor (PEDF)-Based Therapy Induced Photoreceptor Survival by Stabilizing Choroidal Neovessels in a VEGF Overexpression CNV Rat Model. [PDF]

FASEB J
Stabilizing choroidal neovessels offers a novel treatment‐option for pathological CNV. Pigment epithelium‐derived factor (PEDF), a multifunctional protein with vessel‐stabilizing properties, is a promising candidate for this approach. Its efficacy with and without bevacizumab was tested in a VEGF overexpression CNV rat model.
Tschulakow AV, Xi L, Schraermeyer U, Julien S.   +3 more
europepmc   +2 more sources

Otosclerosis and the evolution of stapes surgery: A historical and otopathological study. [PDF]

Laryngoscope Investig Otolaryngol
This study reviews the historical evolution of surgical techniques for treating otosclerosis by examining temporal bone specimens and literature. Early methods like stapes mobilization and fenestration had limited success and notable complications, whereas the development of stapedectomy and stapedotomy significantly improved outcomes ...
Rajan D, Cureoglu S, Adams ME, Monsanto R.   +3 more
europepmc   +2 more sources

AMPKα Silencing Prevents Kanamycin‐Induced Ototoxicity in an Acute Mouse Model

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
Kanamycin plus furosemide (KM + FU) treatment (acute ototoxic model) causes AMPKα activation and rapidly induces cochlear outer hair cell (OHC) loss. Silencing AMPKα1 via posterior semicircular canal injection 48 h before KM + FU treatment reduces this damage, preserving OHCs and hearing.
Shengyu Zou, Fan Wu, Qiaojun Fang, Zuhong He, Hongguo Su, Shan Xu, Su‐Hua Sha   +6 more
wiley   +1 more source

Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He, Mengyao Qu, Lu Yu, Lipeng He, Yixun Lu, Jin Hong, Miao Sun, Huikai Yang, Weidong Mi, Hang Guo, Yulong Ma   +10 more
wiley   +1 more source

Transfer cells in Horneophyton lignieri illuminate the origin of vascular tissues in land plants

New Phytologist, Volume 249, Issue 6, Page 3149-3164, March 2026.
Summary Recent fossil discoveries and advances in plant phylogeny have renewed debate about the most recent common ancestor (MRCA) of land plants and the evolution of its fundamental organs and tissues. We re‐investigate the vascular system of Horneophyton lignieri, an exceptionally preserved Rhynie Chert fossil central to understanding early plant ...
Paul Kenrick, Emma J. Long
wiley   +1 more source

Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs‐On‐Chips

Advanced Biology, Volume 10, Issue 2, February 2026.
Buck and Bugter et al. explore the architectural diversity and physiological functions of human barrier systems and reveal how organ‐on‐chip platforms, particularly those integrating patient‐derived cells, are advancing barrier disease modeling. They highlight how emerging biological and technological advances can be used to bridge the gap between ...
Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler   +4 more
wiley   +1 more source

Time Course of Structural, Functional, Complement Changes and Inflammatory Processes in a Sodium Iodate Rat Model of Geographic Atrophy

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
A sodium iodate (NaIO3)‐induced geographic atrophy (GA) model in pigmented rats was established using in vivo and histological analyses. Morphological, ultrastructural changes, complement and inflammatory processes were evaluated at pre‐dose and 3, 7, and 14 days post‐NaIO3 injection.
Shiying Zhao, Florian Voegele, Jiaqi Tang, Simon J. Clark, Alexander V. Tschulakow, Sylvie Julien   +5 more
wiley   +1 more source

Antimicrobial prescribing guidelines for horses in Australia

Australian Veterinary Journal, Volume 103, Issue 12, Page 781-889, December 2025.
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, as it is unlikely that new antimicrobials will become available for use in horses.
L Hardefeldt, K Thomas, S Page, J Norris, G Browning, C El Hage, A Stewart, J Gilkerson, G Muscatello, D Verwilghen, G van Galen, J Bauquier, R Cuming, B Reynolds, C Whittaker, E Wilkes, J Clulow, C Burden, L Begg   +18 more
wiley   +1 more source

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source