Results 91 to 100 of about 10,405 (214)

Silent zone detection in asthma and its relation to T2 inflammation

Egyptian Journal of Chest Disease and Tuberculosis
Objective Study objectives are to detect small airways disease in asthma and to study T2 inflammatory markers (eosinophil count, IgE, phenotyping) in association with small airways disease.
Hala Samaha, Dalia Elhassan, Afnan Tayeb
doaj   +1 more source

Switching from multiple-inhaler triple therapy to single, extra fine-inhaler triple therapy in severe refractory asthma with EGPA: beyond control. Case report and review of the literature

Drugs in Context
Eosinophilic granulomatosis with polyangiitis is a rare systemic vasculitis associated with asthma, eosinophilia and multi-organ involvement. This case report describes a 69-year-old male with severe, poorly controlled asthma who was diagnosed with ...
Francesco Menzella, Marcello Cottini, Silvia Tonin, Lorenzo Corsi, Annamaria Bosi, Andrea Ballarin, Ariel Floriani, Cristina Dartora, Matteo Tacconi, Carlo Lombardi   +9 more
doaj   +1 more source

Adipokines in Obese Asthma: A Complex Relationship Influenced More by Sex, Weight, and Oral Steroid Treatment Than Disease Severity

Allergy, Volume 81, Issue 9, Page 3206-3220, September 2026.
Adipokine secretion from adipose tissue may be involved in obesity‐related asthma, but it is unknown how adipokine levels relate to asthma characteristics. Plasma adipokines were measured in well‐characterized lean, overweight or obese patients with mild‐to‐moderate or severe asthma.
Lars I. Andersson, Maciej Kupczyk, Barbro Dahlén, Kenji Izuhara, Mina Gaga, Nikos M. Siafakas, Alberto Papi, Bianca Beghe, Guy Joos, Klaus F. Rabe, Elisabeth H. Bel, Sebastian L. Johnston, Pascal Chanez, Mark Gjomarkaj, Peter H. Howarth, Ewa Niżankowska‐Mogilnicka, Roelinde Middelveld, Sven‐Erik Dahlén, Apostolos Bossios, Anna James, on behalf of the BIOAIR (Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease) and ChAMP consortia   +20 more
wiley   +1 more source

Azithromycin on serum FeNO, IgE, and eosinophil levels in bronchiectasis patients [PDF]

Caspian Journal of Internal Medicine
Background: Azithromycin, a macrolide antibiotic with notable anti-inflammatory properties, is widely used in the treatment of bronchiectasis. This study aimed to assess changes in serum fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE), and
Niloofar Keikhaei, Seyedeh Hatameh Asadinejad Tahergourabi, Seyed Ali Javad-Mousavi, Vahan Moradians   +3 more
doaj  

Tezepelumab for early-onset severe allergic asthma with persistent airflow limitation and small airway dysfunction: a treatable traits approach

Drugs in Context
We report the case of an 18-year-old woman with early-onset severe allergic asthma and no other type 2 biomarkers except the presence of IgE, complicated by persistent airflow limitation, air trapping and forced oscillation technique-defined small airway
Francesco Menzella, Claudio Sorino, Carlo Lombardi, Annamaria Bosi, Silvia Tonin, Lorenzo Corsi, Andrea Ballarin, Marcello Cottini   +7 more
doaj   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

Allergy, Volume 81, Issue 9, Page 3345-3360, September 2026.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton, Manuel A. R. Ferreira, Wei Keat Lim, Carlo Sidore, Matthew F. Wipperman, Wenzhen Ge, Xue Song, Changming Xia, Julie E. Horowitz, Andrea T. Hooper, Sara C. Hamon, Jennifer Maloney, Jamie M. Orengo, Zhen Chen, Stephanie Amato Ricci, Bolanle Akinlade, Aris Baras, Gary Herman, Brandy L. Bennett, George D. Yancopoulos   +19 more
wiley   +1 more source

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, Volume 81, Issue 9, Page 3107-3129, September 2026.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

Influência do grupo genético e da alimentação sobre o desempenho de cordeiros em confinamento

Pesquisa Agropecuária Brasileira, 2003
O objetivo deste trabalho foi estabelecer a influência do reprodutor e da alimentação sobre o desempenho de cordeiros em confinamento. O delineamento experimental foi o inteiramente casualizado, com arranjo fatorial 2x4, costituído de dois grupos ...
Barros Nelson Nogueira, Vasconcelos Vânia Rodrigues de, Araújo Marcelo Renato Alves de, Martins Espedito Cezário   +3 more
doaj  

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, Volume 81, Issue 9, Page 3261-3272, September 2026.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Remission in Global Airway Diseases: EUFOREA Consensus Paper

Allergy, Volume 81, Issue 9, Page 3146-3156, September 2026.
ABSTRACT The therapeutic goal in chronic airway diseases is shifting from symptom control to disease remission. Disease‐modifying therapies, including biologics and allergen immunotherapy, have made remission achievable in patients with severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), or allergic rhinitis (AR).
J. Christian Virchow, Xander Bertels, Vibeke Backer, Benjamin S. Bleier, Marco Caminati, Diego M. Conti, Eugenio De Corso, Mina Gaga, Valerie J. Lund, Corrado Pelaia, Anju T. Peters, Glenis K. Scadding, Martin Wagenmann, Riyad O. Al‐Lehebi, Guy G. Brusselle, Philippe Gevaert, Liam G. Heaney, Stella E. Lee, Florence Schleich, Frederik Trinkmann, Peter W. Hellings, Wytske J. Fokkens, Paola Rogliani   +22 more
wiley   +1 more source