Results 141 to 150 of about 533,740 (272)

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

Advanced Science, EarlyView.
Reprogramming the tumor immune microenvironment is crucial for transforming immune “cold” tumors into “hot” inflammatory tumors. The investigation reveals that the combination of ICAM‐1‐Dxd with B7‐H3‐CD3 bispecific antibodies not only demonstrates significant inhibitory effects on tumor growth and metastasis but also plays a vital role in ...
Shoubing Zhou, Mengyu Hong, Dan Zhao, Wenyu Li, Xiaolong Yuan, Yinghong Wang, Hualong Li, Yang Yang, Tengchuan Jin, Jing Pan   +9 more
wiley   +1 more source

Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction

Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023
The last dimerization step of actinorhodin (ACT) biosynthesis was established through biochemical studies. ActVA‐ORF4 is a unique NAD(P)H‐dependent enzyme that catalyzes the biaryl‐coupling reaction using 8‐hydroxydihydrokalafungin (DHK‐OH) as the sole substrate. ActVA‐ORF3 is a quinone‐forming enzyme that forms DHK‐OH and ACT.
Makoto Hashimoto, Susumu Watari, Takaaki Taguchi, Kazuki Ishikawa, Takuya Kumamoto, Susumu Okamoto, Koji Ichinose   +6 more
wiley   +2 more sources

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Preparative‐Scale Biocatalytic Oxygenation of N‐Heterocycles with a Lyophilized Peroxygenase Catalyst

Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023
A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H) is a highly effective catalyst for the oxygenation of a diverse range of N‐heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca.
Balázs Pogrányi, Tamara Mielke, Alba Díaz‐Rodríguez, Jared Cartwright, William P. Unsworth, Gideon Grogan   +5 more
wiley   +2 more sources

Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact. [PDF]

Microorganisms
Elazzazy AM, Baeshen MN, Alasmi KM, Alqurashi SI, Desouky SE, Khattab SMR.   +5 more
europepmc   +1 more source

Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma

Advanced Science, EarlyView.
Enhancer eccANKRD28‐manipulated MM cells have been demonstrated to facilitate drug resistance and promote MM progression by activating the key transcription factor, POU2F2. POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes (IRF4, JUNB, IKZF3, et al.
Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou   +12 more
wiley   +1 more source

Structure‐Guided Engineering of a Versatile Urethanase Improves Its Polyurethane Depolymerization Activity

Advanced Science, EarlyView.
The crystal structures of UMG‐SP2, a metagenome‐derived urethanase that degrades polyurethane, have been solved at high resolution in both ligand‐free and ligand‐bound forms with an amidase inhibitor or a small carbamate. Structure‐guided engineering of UMG‐SP2 improves the understanding of polyurethane degradation mechanisms and generates enzyme ...
Zhishuai Li, Xu Han, Lin Cong, Parinita Singh, Pedro Paiva, Yannick Branson, Wenshuo Li, Yangyang Chen, Da'san M. M. Jaradat, Frank Lennartz, Thomas Bayer, Louis Schmidt, Ulrike Garscha, Song You, Pedro Alexandrino Fernandes, Maria João Ramos, Uwe T. Bornscheuer, Gert Weber, Ren Wei, Weidong Liu   +19 more
wiley   +1 more source

Research progress on fermentation-produced plant-derived bioactive peptides. [PDF]

Front Pharmacol
Zhao L, Liu X, Wang S, Yin Z, An T, Zhang J, Liu Y.   +6 more
europepmc   +1 more source