Results 31 to 40 of about 63,840 (215)

The oxidoreductase activity of Rnf balances redox cofactors during fermentation of glucose to propionate in Prevotella

Scientific Reports, 2023
Propionate is a microbial metabolite formed in the gastrointestinal tract, and it affects host physiology as a source of energy and signaling molecule. Despite the importance of propionate, the biochemical pathways responsible for its formation are not ...
Bo Zhang, Christopher Lingga, Hannah De Groot, Timothy J. Hackmann   +3 more
doaj   +1 more source

Exploiting photosynthesis-driven P450 activity to produce indican in tobacco chloroplasts

Frontiers in Plant Science, 2023
Photosynthetic organelles offer attractive features for engineering small molecule bioproduction by their ability to convert solar energy into chemical energy required for metabolism.
Silas B. Mellor, James B. Y. H. Behrendorff, James B. Y. H. Behrendorff, Johan Ø. Ipsen, Christoph Crocoll, Tomas Laursen, Elizabeth M. J. Gillam, Mathias Pribil   +7 more
doaj   +1 more source

Immunological comparison of ferredoxins [PDF]

FEBS Letters, 1975
1. Introduction The biological significance of ferredoxins in various processes, and the increasing number of them that have been isolated and characterized from bacterial, plant and animal systems, have stimulated investigations on the physico-chemical properties of these proteins [ 1,2].
Tel-Or, E., Cammack, R., Hall, D.O.
openaire   +2 more sources

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

The energy-converting hydrogenase Ech2 is important for the growth of the thermophilic acetogen Thermoanaerobacter kivui on ferredoxin-dependent substrates

Microbiology Spectrum
Thermoanaerobacter kivui is the thermophilic acetogenic bacterium with the highest temperature optimum (66°C) and with high growth rates on hydrogen (H2) plus carbon dioxide (CO2).
Christoph Baum, Benjamin Zeldes, Anja Poehlein, Rolf Daniel, Volker Müller, Mirko Basen   +5 more
doaj   +1 more source

Purification and structural characterization of the Na+-translocating ferredoxin: NAD+ reductase (Rnf) complex of Clostridium tetanomorphum

Nature Communications, 2022
Rnf reversibly reduces NAD+ by ferredoxin coupled with Na+/H+ pumping for microbial ion gradient or reduced ferredoxin formation. Here, a cryo-EM structure provides information about the participating iron and flavin cofactors, the electron transfer ...
Stella Vitt, Simone Prinz, Martin Eisinger, Ulrich Ermler, Wolfgang Buckel   +4 more
doaj   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

A dynamic protein interactome drives energy conservation and electron flux in Thermococcus kodakarensis

Applied and Environmental Microbiology
Life is supported by energy gains fueled by catabolism of a wide range of substrates, each reliant on the selective partitioning of electrons through redox (reduction and oxidation) reactions.
Sere A. Williams, Danielle M. Riley, Teagan P. Rockwood, David A. Crosby, Katherine D. Call, Jared J. LeCuyer, Thomas J. Santangelo   +6 more
doaj   +1 more source

Genetic Variation in Metronidazole Metabolism and Oxidative Stress Pathways in Clinical Giardia lamblia Assemblage A and B Isolates [Corrigendum]

Infection and Drug Resistance, 2021
Saghaug CS, Klotz C, Kallio JP, et al. Infect Drug Resist. 2019;12:1221–1235. The authors have advised NR-1 was used throughout the paper to denote the gene named in GiardiaDB as “Nitroreductase family protein fused to ferredoxin domain Fd ...
Saghaug CS, Klotz C, Kallio JP, Brattbakk HR, Stokowy T, Aebischer T, Kursula I, Langeland N, Hanevik K   +8 more
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