Results 81 to 90 of about 89,729 (302)

Evolutionary Relationships Between Low Potential Ferredoxin and Flavodoxin Electron Carriers

Frontiers in Energy Research, 2019
Proteins from the ferredoxin (Fd) and flavodoxin (Fld) families function as low potential electrical transfer hubs in cells, at times mediating electron transfer between overlapping sets of oxidoreductases.
Ian J. Campbell, George N. Bennett, George N. Bennett, Jonathan J. Silberg, Jonathan J. Silberg, Jonathan J. Silberg   +5 more
doaj   +1 more source

Energy Conservation in Fermentations of Anaerobic Bacteria

Frontiers in Microbiology, 2021
Anaerobic bacteria ferment carbohydrates and amino acids to obtain energy for growth. Due to the absence of oxygen and other inorganic electron acceptors, the substrate of a fermentation has to serve as electron donor as well as acceptor, which results ...
Wolfgang Buckel
doaj   +1 more source

Inactivation of clostridial ferredoxin and pyruvate-ferredoxin oxidoreductase by sodium nitrite [PDF]

Applied and Environmental Microbiology, 1987
Clostridial ferredoxin and pyruvate-ferredoxin oxidoreductase activity was investigated after in vitro or in vivo treatment with sodium nitrite. In vitro treatment of commercially available Clostridium pasteurianum ferredoxin with sodium nitrite inhibited ferredoxin activity.
Carpenter, C. E., Reddy, D. S. A., Cornforth, Daren P.   +2 more
openaire   +3 more sources

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

A dynamic protein interactome drives energy conservation and electron flux in Thermococcus kodakarensis

Applied and Environmental Microbiology
Life is supported by energy gains fueled by catabolism of a wide range of substrates, each reliant on the selective partitioning of electrons through redox (reduction and oxidation) reactions.
Sere A. Williams, Danielle M. Riley, Teagan P. Rockwood, David A. Crosby, Katherine D. Call, Jared J. LeCuyer, Thomas J. Santangelo   +6 more
doaj   +1 more source

Electron Bifurcation and Confurcation in Methanogenesis and Reverse Methanogenesis

Frontiers in Microbiology, 2018
Reduction of the disulfide of coenzyme M and coenzyme B (CoMS–SCoB) by heterodisulfide reductases (HdrED and HdrABC) is the final step in all methanogenic pathways. Flavin-based electron bifurcation (FBEB) by soluble HdrABC homologs play additional roles
Zhen Yan, James G. Ferry
doaj   +1 more source

Metabolic network analysis reveals microbial community interactions in anammox granules. [PDF]

, 2017
Microbial communities mediating anaerobic ammonium oxidation (anammox) represent one of the most energy-efficient environmental biotechnologies for nitrogen removal from wastewater.
Bhattacharjee, Ananda S, Goel, Ramesh, Hamilton, Joshua J, Lawson, Christopher E, McMahon, Katherine D, Noguera, Daniel R, Wu, Sha   +6 more
core   +2 more sources

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Oxidation of P700 Induces Alternative Electron Flow in Photosystem I in Wheat Leaves

Plants, 2019
Oxygen (O2)-evolving photosynthetic organisms oxidize the reaction center chlorophyll, P700, in photosystem I (PSI) to suppress the production of reactive oxygen species.
Kanae Kadota, Riu Furutani, Amane Makino, Yuji Suzuki, Shinya Wada, Chikahiro Miyake   +5 more
doaj   +1 more source