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Ferredoxin 1-like maintains iron homeostasis and hepatoma cell survival

Free Radical Biology and Medicine
Ferredoxin 1-like (FDX1L) is a pivotal component of the core iron-sulfur (Fe-S) cluster assembly machinery. However, the role of FDX1L in hepatocellular carcinoma (HCC) has not been thoroughly elucidated. In this study, we conducted genome-wide CRISPR-Cas9 screenings and identified FDX1L as an essential gene for hepatoma cell survival.
Jie Zheng   +9 more
openaire   +2 more sources

The emerging role of ferredoxin 1 in cancer: Insights into cuproptosis and therapeutic innovation

International Journal of Biological Macromolecules
Ferredoxin 1 (FDX1), a key component of the mitochondrial electron transport chain, is crucial in the copper-mediated cell death pathway known as cuproptosis. Located at the q22.3 locus on chromosome 11, FDX1 acts as a reductase and is integral to cellular redox reactions and energy metabolism.
Annan, Wu, Kai, Tu, Guangfeng, Xia
openaire   +2 more sources

Primary leaf‐type ferredoxin 1 participates in photosynthetic electron transport and carbon assimilation in rice

The Plant Journal, 2020
SUMMARYFerredoxins (Fds) play a crucial role in photosynthesis by regulating the distribution of electrons to downstream enzymes. Multiple Fd genes have been annotated in the Oryza sativa L. (rice) genome; however, their specific functions are not well understood. Here, we report the functional characterization of rice Fd1.
Lei He   +16 more
openaire   +2 more sources

DEVELOPMENT OF IMMUNOASSAYS FOR THE IRON‐REGULATED PROTEINS FERREDOXIN AND FLAVODOXIN IN POLAR MICROALGAE1

Journal of Phycology, 2009
While the growth of Southern Ocean phytoplankton is often limited by iron availability, there are no comparable experiments on sea‐ice algae. Here we assess the use of ferredoxin and flavodoxin to investigate the iron nutritional status of sea‐ice algae and describe the development of a quantitative immunoassay for both proteins in marine diatoms. High‐
Andrew, Pankowski, Andrew, McMinn
openaire   +2 more sources

Characterization of aldehyde ferredoxin oxidoreductase gene defective mutant in Magnetospirillum magneticum AMB-1

Biochemical and Biophysical Research Communications, 2003
A non-magnetic mutant of Magnetospirillum magneticum AMB-1, designated as NMA21, was generated by mini-Tn5 transposon mutagenesis to identify genes involved in bacterial magnetic particle (BMP) synthesis. Alignment of the DNA sequences flanking the transposon allowed the isolation of an open reading frame (ORF2) within an operon consisting of five ...
Aris Tri, Wahyudi   +4 more
openaire   +2 more sources

Two sites of interaction of ferredoxin with thylakoids [PDF]

open access: yesFEBS Letters, 1985
The interaction of ferredoxin with thylakoids is shown to occur at two distinct sites: at the reducing end of photosystem I, and at the site where ferredoxin-NADP reductase (FNR) is located on the membrane. The evidence is based on the lack of inhibition
Forti, Giorgio   +3 more
exaly   +2 more sources

Abstract 4464: Ferredoxin 1 is essential for embryonic development and lipid homeostasis

Cancer Research
Abstract Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways.
Jin Zhang   +4 more
openaire   +1 more source

Cloning and expression of the ferredoxin gene from extremely halophilic archaeon Haloarcula japonica strain TR-1

Biometals, 2001
The gene encoding a ferredoxin (Fd) from Haloarculajaponica strain TR-1 was cloned and sequenced. Sequence analysis of the cloned Ha. japonica Fd gene revealed that the structural gene consisted of an open reading frame of 387 nucleotides encoding 129 amino acids. The deduced amino acid sequence of Ha.
T, Matsuo   +5 more
openaire   +2 more sources

The Inheritance and Linkage Mapping of Ferredoxin-1 in Pea

Journal of Heredity, 1991
N. O. Polans   +3 more
openaire   +1 more source

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