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Assessment of serum ferritin as a biomarker in COVID-19: bystander or participant? Insights by comparison with other infectious and non-infectious diseases

Biomarkers, 2020
Background The 2019 coronavirus disease (COVID-19) caused by the SARS-CoV-2 virus has an impact on all aspects of patient care. Serum ferritin generally represents a biomarker of choice when iron deficiency is suspected.
K. Kappert, Amir Jahic, R. Tauber
semanticscholar   +1 more source

Interaction of ferritin with serum: implications for ferritin turnover

Clinica Chimica Acta, 1984
An interaction between human and rabbit ferritins and serum was demonstrated by a coated tube binding assay, a shift in molecular size on gel filtration and by precipitation of complexes with 3.5% polyethylene glycol 6000. With polyethylene glycol and labelled ferritins, complex formation was inhibited by heating sera to 56 degrees C for 30 min and by ...
A M, Covell, A, Jacobs, M, Worwood
openaire   +2 more sources

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

open access: yesNature Communications, 2015
Brain iron elevation is implicated in Alzheimer’s disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study.
Scott Ayton, Noel Faux, Ashley Bush
exaly   +2 more sources

Reactivity of ferritin and the structure of ferritin-derived ferrihydrite

Biochimica et Biophysica Acta (BBA) - General Subjects, 2010
In nature or in the laboratory, the roughly spherical interior of the ferritin protein is well suited for the formation and storage of a variety of nanosized metal oxy-hydroxide compounds which hold promise for a range of applications. However, the linkages between ferritin reactivity and the structure and physicochemical properties of the nanoparticle
F Marc, Michel   +5 more
openaire   +2 more sources

Differential localization of ferritin and ferritin immune complexes in the spleen: Influence of the charge of ferritin

Clinical Immunology and Immunopathology, 1986
Prior studies have demonstrated that following administration to animals most antigens (Ag) localize within the red pulp whereas immune complexes (IC) are found in the white pulp. Using ferritin and ferritin IC, we describe a striking different localization of the Ag alone compared with the same AG complexed with its antibody.
C, Genin, A F, Michael
openaire   +2 more sources

A plasma ferritin is not always a serum ferritin

Pathology, 2015
Aim Ferritin is an iron-storage protein with plasma levels used as an indicator of iron deficiency. We undertook parallel testing of ferritin levels in serum and plasma to measure the range of variation and we present data for specimens from a panel of otherwise healthy volunteers.
Yu Ji   +3 more
openaire   +1 more source

Ferritin: Diversity and Management of Ferritin Measurement Methods

2018
Serum ferritin is one of the most important and widely used markers of iron metabolism, and is a recommended standard index of iron dynamics in guidelines for renal anemia in many countries. However, serum ferritin measurement has several disadvantages.
Daigo, Kamei   +5 more
openaire   +2 more sources

Ferritin heavy/light chain (FTH1/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia

European Journal of Haematology, 2018
We previously reported the prognostic value of serum ferritin in younger patients with intermediate‐risk acute myeloid leukemia (AML). The aims of this study were to confirm this finding in a larger cohort regardless of age and prognostic subgroups, to ...
S. Bertoli   +16 more
semanticscholar   +1 more source

The Ferritin Superfamily

2017
Iron is very important in many biological processes and the ferritin protein family has evolved to store iron and to maintain cellular iron homeostasis. The deletion of the coding gene for the H subunit of ferritin leads to early embryonic death in mice and mutations in the gene for the L subunits in humans has been observed in neurodegenerative ...
openaire   +2 more sources

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