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Biology of the iron efflux transporter, ferroportin

2021
Iron, the most common metal in the earth, is also an essential component for almost all living organisms. While these organisms require iron for many biological processes, too much or too little iron itself poses many issues; this is most easily recognized in human beings.
Rishi, Gautam, Subramaniam, V. Nathan
openaire   +3 more sources

Iron transporter ferroportin FPN1

2003
Iron is a major component of the Earth’s crust, but its own chemistry greatly limits its utilization and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration.
openaire   +2 more sources

Ferroportin disease: A novel SLC40A1 mutation

Digestive and Liver Disease, 2020
Ravasi G.   +4 more
openaire   +2 more sources

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Nature, 2020
Christian Bache Billesbølle   +2 more
exaly  

Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin

EMBO Journal, 2007
Maria Carmela Bonaccorsi di Patti   +2 more
exaly  

FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels

Nature Nanotechnology, 2019
Edwin C Pratt   +2 more
exaly  

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