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Biology of the iron efflux transporter, ferroportin
2021Iron, the most common metal in the earth, is also an essential component for almost all living organisms. While these organisms require iron for many biological processes, too much or too little iron itself poses many issues; this is most easily recognized in human beings.
Rishi, Gautam, Subramaniam, V. Nathan
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Iron transporter ferroportin FPN1
2003Iron is a major component of the Earth’s crust, but its own chemistry greatly limits its utilization and also sets the basis for its toxicity. The capacity of readily exchanging electrons in aerobic conditions makes iron essential for fundamental cell functions, such as DNA synthesis, transport of oxygen and electrons, and cell respiration.
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Ferroportin disease: A novel SLC40A1 mutation
Digestive and Liver Disease, 2020Ravasi G. +4 more
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Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
Nature, 2020Christian Bache Billesbølle +2 more
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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Cell Metabolism, 2005Nancy C Andrews
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FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels
Nature Nanotechnology, 2019Edwin C Pratt +2 more
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