Results 191 to 200 of about 115,871 (339)

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling [PDF]

, 2019
Jiao Wu, Alexander M. Minikes, Minghui Gao, Huijie Bian, Yong Li, Brent R. Stockwell, Zhi‐Nan Chen, Xuejun Jiang   +7 more
openalex   +1 more source

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

Advanced Science, EarlyView.
We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang, Laura Leiskau, Lea Bambach, Marcel Deponte   +3 more
wiley   +1 more source

Ferroptosis in cancer (Review)

Oncology Letters
Ferroptosis is a type of programmed cell death depending on iron and reactive oxygen species. This unique cell death process has attracted a great deal of attention in the field of cancer research over the past decade. Research on the association of ferroptosis signal pathways and cancer development indicated that targeting ferroptosis has great ...
Zeng, Liyi, Liu, Xiaohui, Geng, Chengjie, Gao, Xuejuan, Liu, Langxia   +4 more
openaire   +2 more sources

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation

Cell Death Discovery
Ferroptosis represents a distinct form of programmed cell death triggered by excessive iron accumulation and lipid peroxidation-induced damage. This mode of cell death differentiates from classical programmed cell death in terms of morphology and ...
Xin Jin, Jiuren Tang, Xiangyu Qiu, Xiaoya Nie, Shengming Ou, Geyan Wu, Rongxin Zhang, Jinrong Zhu   +7 more
doaj   +1 more source

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis [PDF]

, 2019
Yilong Zou, Michael J. Palte, Amy Deik, Haoxin Li, John K. Eaton, Wenyu Wang, Yuen‐Yi Tseng, Rebecca Deasy, Maria Kost‐Alimova, Vlado Dančík, Elizaveta S. Leshchiner, Vasanthi S. Viswanathan, Sabina Signoretti, Toni K. Choueiri, Jesse S. Boehm, Bridget K. Wagner, John G. Doench, Clary B. Clish, Paul A. Clemons, Stuart L. Schreiber   +19 more
openalex   +1 more source

PM2.5 Induce Endothelial‐Mesenchymal Transition and Cardiac Fibrosis via the NCOA4‐Mediated Ferritinophagy

Advanced Science, EarlyView.
This study primarily reveals that PM2.5‐derived Fe‐containing particles, particularly magnetite, are specifically enriched in the heart. Here, they interact with NCOA4 in endothelial cells, disrupt iron homeostasis by enhancing ferritinophagy, and subsequently trigger the process of EndMT through the NCOA4/KLF5 pathway.
Qinglin Sun, Mengyuan Wang, Lin Liu, Ruiyang Ding, Kanglin Yan, Shiqian Liu, Xiaoke Ren, Qing Xu, Zhiwei Sun, Qian Liu, Yi Yang, Junchao Duan   +11 more
wiley   +1 more source

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

, 2018
Ron Shah, Mikhail S. Shchepinov, Derek A. Pratt   +2 more
openalex   +1 more source

Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity

Advanced Science, EarlyView.
A novel hybrid gene delivery platform combines adeno‐associated virus (AAV)‐mediated receptor‐interacting kinase 3 (RIPK3) expression with manganese dioxide‐polyethyleneimine (MnO2−PEI) nanoshield to induce necroptosis, ferroptosis, and immunogenic cell death, effectively reprogramming the tumor microenvironment.
Soo‐Hwan Lee, Yunkyeong Cho, Seunghwan Bang, Daeun Sung, Jahyun Koo, Seoyoung Kim, Youngil Koh, Hojun Kim, Hyojin Lee   +8 more
wiley   +1 more source

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

, 2018
Michael M. Gaschler, Alexander A. Andia, Hengrui Liu, J. Csuka, Brisa Hurlocker, Christopher A. Vaiana, Daniel W. Heindel, Dylan S. Zuckerman, Pieter H. Bos, Eduard Reznik, Ling F. Ye, Yulia Y. Tyurina, Annie Lin, Mikhail S. Shchepinov, Amy Chan, Eveliz Peguero-Pereira, Maksim A. Fomich, Jacob D. Daniels, Andrei V. Bekish, Vadim V. Shmanai, Valerian E. Kagan, Lara K. Mahal, K. A. Woerpel, Brent R. Stockwell   +23 more
openalex   +2 more sources