Results 171 to 180 of about 112,447 (264)

Ferroptosis blockade: beyond preservation to active graft therapy. [PDF]

Signal Transduct Target Ther
Xing C, Oniscu GC, Lauschke VM.
europepmc   +1 more source

Decoding the Ferroptosis-Related Gene Signatures and Immune Infiltration Patterns in Ovarian Cancer: Bioinformatic Prediction Integrated with Experimental Validation [PDF]

Beilei Zhang,1,* Bin Guo,1,* Hancun Kong,2,* Linwei Yang,2 Hui Yan,2 Jierui Liu,2 Yichen Zhou,2 Ruifang An,1 Fu Wang2– 4 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi ...
An R, Liu J, Yang L, Wang F, Guo B, Zhou Y, Zhang B, Yan H, Kong H   +8 more
core  

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source

Induction of transferrin receptor 1-mediated ferroptosis by ultrasound-triggered microbubble destruction sensitizes glioblastoma to radiotherapy. [PDF]

Mol Biomed
He Y, Dong X, Lu X, Zhu Q, Miao Q, Yan Z, Zhao Q, Chen H, Qin M, Yi Y, Li J, Yang D, Zhang H, Xu Y, Chen M, Bian X, Hua X.   +16 more
europepmc   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Histone Post-Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations. [PDF]

Cell Biochem Funct
Tang X, Luo H, Gao S, Liu X, Sun Q, Zeng Y.   +5 more
europepmc   +1 more source

Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy

Xiudan Li,1,2 Lifeng Gao,2 Xuyang Li,2 Jingdong Xia,1 Yurong Pan,1 Chunying Bai2 1Department of Endocrinology, Affiliated Hospital of Chifeng University, Chifeng, 024000, China; 2Inner Mongolia Key Laboratory of Human Genetic Disease Research, Chifeng ...
Li X, Bai C, Xia J, Pan Y, Gao L
core  

Roles and Mechanisms of Ferroptosis in Sorafenib Resistance for Hepatocellular Carcinoma [PDF]

Ruyuan Liu,1,* Huanyu Cui,1,* Di Li,1 Xuefeng Guo,1 Zhengbao Zhang,1 Shengkui Tan,1,2 Xiaonian Zhu1 1Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, Guilin Medical University, Guilin, 541199, People’s Republic of ...
Li D, Zhang Z, Guo X, Cui H, Tan S, Liu R, Zhu X   +6 more
core  

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source