Results 151 to 160 of about 112,447 (264)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Ferroptosis as a target mechanism in heart and kidney disease. [PDF]

J Clin Invest
Singh SJ, Cheema B, Ardehali H.
europepmc   +1 more source

Vitamin C enhanced erastin-induced ferroptosis in drug-resistant colorectal cancer cells and in CAM-derived xenografts

Recent studies indicated that the induction of ferroptosis, a type of non-apoptotic and iron-dependent form of cell death, could be a promising therapeutic approach for eradicating drug-resistant colorectal cancer (CRC) cells.
Giulia Russo, Annalisa Pecoraro, Chiara Brignola, Annapina Russo, Camilla Danisi   +4 more
core  

Gandouling Regulates Ferroptosis and Improves Neuroinflammation in Wilson’s Disease Through the LCN2/NLRP3 Signaling Pathway [PDF]

Yuya Wen,1 Chenling Zhao,1 Jie Chen,1 Liwei Tian,1 Bojin Wu,1 Wenting Xie,1 Ting Dong1,2 1Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230031, People’s Republic of China; 2Key Laboratory of Xin’An
Wen Y, Dong T, Tian L, Xie W, Zhao C, Chen J, Wu B   +6 more
core  

Machine Learning Diagnostic Model for Hepatocellular Carcinoma Based on Liquid–Liquid Phase Separation and Ferroptosis-Related Genes

Background/Aims: Hepatocellular carcinoma (HCC) represents a primary liver malignancy with a multifaceted molecular landscape. The interplay between liquid–liquid phase separation (LLPS) and ferroptosis—a regulated form of cell death—has garnered ...
Ting Zhu, Linlin Zhao, Xin Zhong, Wenchao Chen, Suihan Wang, Tianyu Lin, Xiaofan Pu, Senhao Zhou   +7 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Comprehensive Analysis of Angiogenesis and Ferroptosis Genes for Predicting the Survival Outcome and Immunotherapy Response of Hepatocellular Carcinoma [PDF]

Peng Wang, Guilian Kong Department of Nuclear Medicine, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou, Henan, 450003, People’s Republic of ChinaCorrespondence: Guilian Kong,
Wang P, Kong G
core  

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Targeting ferroptosis in ocular diseases: mechanisms, clinical implications, and therapeutic horizons. [PDF]

Int J Ophthalmol
Zhang NY, Kong HQ, Liao YQ, Pan YJ, Sun W, Xi L, Yu HH, Shi YH.   +7 more
europepmc   +1 more source