Results 131 to 140 of about 119,861 (259)

Ferroptosis and aging: Inducing and catalyzing neurodegenerative diseases

Neural Regeneration Research
Ferroptosis is a newly recognized form of programmed cell death characterized by iron overload-dependent lipid peroxidation. These pathological phenomena are often observed in neurodegenerative diseases.
Qifeng Song, Shi Sun, Yuxiu Song, Yashi Wang, Yin Yuan, Lixin Zhang, Qian Cui   +6 more
doaj   +1 more source

Vitamin C enhanced erastin-induced ferroptosis in drug-resistant colorectal cancer cells and in CAM-derived xenografts

Recent studies indicated that the induction of ferroptosis, a type of non-apoptotic and iron-dependent form of cell death, could be a promising therapeutic approach for eradicating drug-resistant colorectal cancer (CRC) cells.
Giulia Russo, Annalisa Pecoraro, Chiara Brignola, Annapina Russo, Camilla Danisi   +4 more
core  

Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development [PDF]

Zhenxiang Zhao,1 Na Xing,2 Hao Guo,3 Jianfeng Li,1 Guozhu Sun4 1Department of Neurosurgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, People’s Republic of China; 2Department of Endocrinology, The Fourth Hospital of Hebei ...
Li J, Guo H, Sun G, Zhao Z, Xing N
core  

Allergy and ferroptosis

Allergic responses are defined by hypersensitive reactions against foreign antigens that activate immune cell interactions, leading B lymphocytes to produce IgE.
Guo, Haiyan, Zhang, Youming, Lei, Mingsheng, Du, Hongchun, Ma, Jinan   +4 more
core   +1 more source

Ferroptosis inducers.

, 2018
Ferroptosis inducers.
Huizhong Feng (4956265), Brent R. Stockwell (30593)   +1 more
core   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Ferroptosis and metabolic reprogramming in the immunosuppressive microenvironment of glioblastoma: emerging mechanisms and novel strategies

Frontiers in Immunology
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. GBM often exhibits resistance to conventional apoptosis-inducing therapies, and its immunosuppressive microenvironment limits the efficacy of existing treatments ...
Liang Han, Zhengming Wang, Yichuan Jiang, Haoyu Zhou, Haixia Zhou   +4 more
doaj   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Programming a Ferroptosis‐to‐Apoptosis Transition Landscape Revealed Ferroptosis Biomarkers and Repressors for Cancer Therapy

Advanced Science
Ferroptosis and apoptosis are key cell‐death pathways implicated in several human diseases including cancer. Ferroptosis is driven by iron‐dependent lipid peroxidation and currently has no characteristic biomarkers or gene signatures.
Yaron Vinik, Avi Maimon, Vinay Dubey, Harsha Raj, Ifat Abramovitch, Sergey Malitsky, Maxim Itkin, Avi Ma'ayan, Frank Westermann, Eyal Gottlieb, Eytan Ruppin, Sima Lev   +11 more
doaj   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source