Results 111 to 120 of about 112,447 (264)

Breaking the Barriers of Therapy Resistance: Harnessing Ferroptosis for Effective Hepatocellular Carcinoma Therapy [PDF]

Xianmei Lv,1,2,* Gaochen Lan,3,* Lujian Zhu,4,* Qiusheng Guo1 1Department of Radiotherapy, Jinhua People’s Hospital, Jinhua, Zhejiang, 321000, People’s Republic of China; 2Department of Oncology, The Second Affiliated Hospital of Fujian ...
Lv X, Zhu L, Lan G, Guo Q
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MCT1 inhibition sensitizes medulloblastoma cells to ferroptosis induction

reservedIl Glioblastoma multiforme (GBM) e il Medulloblastoma (MB) sono due tra i tumori più aggressivi che possono colpire il sistema nervoso centrale.
BREDA, FRANCO
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Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

Gut‐Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction‐Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion

Advanced Science, EarlyView.
Systematic characterization of the liver‐resident microbiota in advanced metabolic dysfunction‐associated steatotic liver disease (MASLD) reveals a consistent depletion of Bacteroides uniformis (B. uniformis) in both hepatic and gut microbial communities. Oral gavage of B.
Haiyang Liu, Zun Fan, Zhen Liu, Lei Qin, Xin Zhao   +4 more
wiley   +1 more source

Iron-Dependent Cell Death: Exploring Ferroptosis as a Unique Target in Triple-Negative Breast Cancer Management [PDF]

Li-kuan Tan,1 Jiaxing Liu,1 Cheng-zhi Ma,1 Shaolong Huang,1 Feng-hui He,1 Yang Long,1 Zhi-sheng Zheng,1 Jia-liang Liang,1 Nan Xu,1 Guanghui Wang,2 Yu-fei Liu1 1Breast Surgery, Tongren People’s Hospital, Tongren, People’s Republic of China; 2Breast ...
He FH, Zheng ZS, Liu J, Huang S, Xu N, Long Y, Liu YF, Ma CZ, Wang G, Tan LK, Liang JL   +10 more
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Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

ZK53 enhances tumor cell susceptibility to ferroptosis via ClpP-mediated mitochondrial dysfunction

Frontiers in Oncology
Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. This process has garnered increasing attention due to its potential as a promising therapeutic strategy for cancer.
Songjun Dai, Tingting Zhang, Xiaoyan Dai, Keke Zheng, Hong Qian, Zhou Tong, Qiang Zhang   +6 more
doaj   +1 more source

IGF2BP1 Bolsters the Chondrocytes Ferroptosis of Osteoarthritis by Targeting m6A/MMP3 Axis [PDF]

Ziqin Zhao,1 Shuhui Dong,1 Yong Yang,1 Haibo Yin,1 Guangyi Xiong,1 Jianxiong Ma2 1Department of Pathology, Tianjin Hospital, Tianjin University, Tianjin, People’s Republic of China; 2Institute of Orthopaedic Surgery, Tianjin Hospital, Tianjin University,
Yin H, Yang Y, Ma J, Zhao Z, Dong S, Xiong G   +5 more
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Uncovering the role of RPL8 in glutathione synthesis-dependent ferroptosis control in hepatocellular carcinoma

Introduction Hepatocellular carcinoma (HCC) is significantly impacted by ferroptosis, a form of regulated cell death linked to iron metabolism and oxidative stress. This process is modulated by glutathione (GSH) levels.
Yiran Li, Hao Zhang, Tao Ye, Jing Luo, Dong Jiang   +4 more
core   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source