Results 91 to 100 of about 112,447 (264)
Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice
Journal of Translational MedicineBackground Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not been clarified, nor have the drugs
Yixiao Xiong +5 more
doaj +1 more source
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches [PDF]
YiLin Luo, Xin Yue Bai, Lei Zhang, Qian Qian Hu, Ning Zhang, Jun Zhi Cheng, Ming Zheng Hou, Xiao Long Liu Yan ‘an Small Molecule Innovative Drug R&D Engineering Research Center, School of Medicine, Yan’an University, Yan’an, People’s Republic of ...
Bai XY +7 more
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Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option? [PDF]
Ferroptosis is a form of iron-dependent regulated cell death caused by the accumulation of lipid peroxides. In this review, we summarize research on the impact of ferroptosis on disease models and isolated cells in various types of arthritis.
Jennifer Amsler +5 more
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Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches
Molecular BiomedicineFerroptosis is a promising programmed cell death modality for cancer therapy, driven by iron overload and the accumulation of phospholipid peroxides that culminate in lethal membrane damage.
Junqi Wang +4 more
doaj +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
Antiferroptosis therapy alleviated the development of atherosclerosis
MedCommFerroptosis has been confirmed to be associated with various diseases, but the relationship between ferroptosis and atherosclerosis (AS) remains unclear.
Zhou Yang +7 more
doaj +1 more source
Immunometabolism of ferroptosis in the tumor microenvironment
Frontiers in OncologyFerroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation in cellular membranes. Within the last decade, physiological and pathological roles for ferroptosis have been uncovered in autoimmune diseases, inflammatory ...
Gian Luca Lupica-Tondo +4 more
doaj +1 more source
The Dual Roles of STAT3 in Ferroptosis: Mechanism, Regulation and Therapeutic Potential [PDF]
Jinghui Xie,* Dan Luo,* Pengfei Xing, Weijun Ding School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weijun ...
Ding W, Xie J, Luo D, Xing P
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Background/Aims: As a very common malignancy of the digestive system, the incidence and mortality rates of gastric cancer (GC) are increasing year by year. The critical role of ferroptosis in cancer development has been well-documented.
Min Zhang +6 more
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