Results 91 to 100 of about 119,861 (259)

Selenium Attenuates Ethanol-induced Hepatocellular Injury by Regulating Ferroptosis and Apoptosis

Background/Aims: Ferroptosis is a newly identified type of cell death which is strongly linked to the development of several diseases. Whereas, the role of ferroptosis in the improvement of ethanol-induced hepatocytes injury by selenium has not been ...
Qianhui Li, Feng Chen, Fei Wang, Xiaomin Xu   +3 more
core   +1 more source

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Inhibition of ferroptosis reverses heart failure with preserved ejection fraction in mice

Journal of Translational Medicine
Background Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of heart failure cases. The molecular mechanisms by which HFpEF leads to impaired diastolic function of the heart have not been clarified, nor have the drugs
Yixiao Xiong, Xin Liu, Ling Jiang, Tao Hao, Yanyan Wang, Tao Li   +5 more
doaj   +1 more source

A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy [PDF]

Lin Jing, Wenguang Xiao, Zhouxing Hu, Xu Liu, Mingqing Yuan Guangxi Key Laboratory of Special Biomedicine; School of Medicine, Guangxi University, Nanning, 530004, People’s Republic of ChinaCorrespondence: Mingqing Yuan, School of Medicine, Guangxi ...
Liu X, Jing L, Hu Z, Xiao W, Yuan M
core  

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease

Journal of Mazandaran University of Medical Sciences, 2021
Ferroptosis is a new type of programmed cell death that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure.
Soghra Farzipour, Fereshteh Talebpour Amiri, Maryam Alvandi, Zahra Shaghaghi, Amirhossein Yazdi   +4 more
doaj  

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches

Molecular Biomedicine
Ferroptosis is a promising programmed cell death modality for cancer therapy, driven by iron overload and the accumulation of phospholipid peroxides that culminate in lethal membrane damage.
Junqi Wang, Dawei Guo, Shanxiang Jiang, Wenda Wu, Xiuge Gao   +4 more
doaj   +1 more source

Pathological Characteristics of Ferroptosis in Kidney Tissues in Type 2 Diabetic Patients with Diabetic Kidney Disease [PDF]

Min Li,1,2 Song Zhao,2 Yan Liu,1 Qian Wang,2 Yongzhe Chen,2 Yaru Zhou1 1Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, People’s Republic of China; 2Department of Nephrology, The Third Hospital of
Liu Y, Zhao S, Wang Q, Chen Y, Zhou Y, Li M   +5 more
core  

Uncovering the role of RPL8 in glutathione synthesis-dependent ferroptosis control in hepatocellular carcinoma

Introduction Hepatocellular carcinoma (HCC) is significantly impacted by ferroptosis, a form of regulated cell death linked to iron metabolism and oxidative stress. This process is modulated by glutathione (GSH) levels.
Yiran Li, Hao Zhang, Tao Ye, Jing Luo, Dong Jiang   +4 more
core   +1 more source