Results 81 to 90 of about 138,617 (359)

The endocannabinoid, anandamide, induces cannabinoid receptor-independent cell death in renal proximal tubule cells [PDF]

, 2017
Background: The endocannabinoid (EC) system is well characterized in the central nervous system but scarcely studied in peripheral organs. In this paper, we newly identify the effect of the EC anandamide (AEA) upon renal proximal tubule cells. Methods:
Barrett, David A., Bindila, Laura, Fries, Jochen W.U., Grau, Veronika, Lutz, Beat, Löser, Heike, Montesinos-Rongen, Manuel, Ortori, Catharine A., Sarmad, Sarir, Schlosser, Monika, Siegmund, Sören V., von Brandenstein, Melanie   +11 more
core   +3 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Ferroptosis in Neurological Diseases [PDF]

Frontiers in Cellular Neuroscience, 2020
Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is crucially involved in neurological diseases, including neurodegeneration, stroke and neurotrauma.
Jia-Xin Ren, Jia-Xin Ren, Xin Sun, Xiu-Li Yan, Zhen-Ni Guo, Yi Yang   +5 more
openaire   +3 more sources

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Frontiers in Pharmacology
Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. Ferroptosis is currently proposed as one of the most promising means of combating tumor resistance.
Kodzo Prosper Adzavon, Weijian Zhao, Xuesong He, Wang Sheng   +3 more
doaj   +1 more source

BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection

Pharmacological Research, 2022
Smooth muscle cell (SMC) loss is the characteristic feature in the pathogenesis of aortic dissection (AD), and ferroptosis is a novel iron-dependent regulated cell death driven by the excessive lipid peroxidation accumulation.
Yue Chen, Xin Yi, Bo Huo, Yi He, Xian Guo, Zihao Zhang, Xiaoxuan Zhong, Xin Feng, Ze-Min Fang, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang   +11 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Oncogenic senescence: a multi-functional perspective. [PDF]

, 2017
Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development.
Alimirah, Fatouma, Baker, Darren J, Campisi, Judith, Hildesheim, Jeffrey, van Deursen, Jan M   +4 more
core  

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death [PDF]

, 2019
In the last decade, it has become clear that anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD).
Balalaeva, Irina, Krysko, Dmitri, Krysko, Olga, Mishchenko, Tatiana, Mitroshina, Elena, Vedunova, Maria   +5 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis

mBio, 2023
Herpes simplex virus 1 (HSV-1) is a DNA virus belonging to the family Herpesviridae. HSV-1 infection causes severe neurological disease in the central nervous system (CNS), including encephalitis.
Xi-Qiu Xu, Tongran Xu, Wenting Ji, Chong Wang, Yujie Ren, Xiaobei Xiong, Xi Zhou, Shu-Hai Lin, Yi Xu, Yang Qiu   +9 more
doaj   +1 more source