Results 161 to 170 of about 138,617 (359)

Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches

Molecular Biomedicine
Ferroptosis is a promising programmed cell death modality for cancer therapy, driven by iron overload and the accumulation of phospholipid peroxides that culminate in lethal membrane damage.
Junqi Wang, Dawei Guo, Shanxiang Jiang, Wenda Wu, Xiuge Gao   +4 more
doaj   +1 more source

Immunometabolism of ferroptosis in the tumor microenvironment

Frontiers in Oncology
Ferroptosis is an iron-dependent form of cell death that results from excess lipid peroxidation in cellular membranes. Within the last decade, physiological and pathological roles for ferroptosis have been uncovered in autoimmune diseases, inflammatory ...
Gian Luca Lupica-Tondo, Emily N. Arner, Denis A. Mogilenko, Kelsey Voss, Kelsey Voss   +4 more
doaj   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Ferroptosis: a new hunter of hepatocellular carcinoma

Cell Death Discovery
Ferroptosis is an iron ion-dependent, regulatory cell death modality driven by intracellular lipid peroxidation that plays a key role in the development of HCC.
Yulang Jiang, Yongxin Yu, Ziyang Pan, Christian Glandorff, Mingyu Sun   +4 more
doaj   +1 more source

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model

, 2020
Wei Yang, Xiaolong Liu, Chunli Song, Sen Ji, Jianhong Yang, Yang Liu, Jing You, Jie Zhang, Shenzhen Huang, Wei Cheng, Zhenhua Shao, Linli Li, Shengyong Yang   +12 more
openalex   +1 more source

Supplementary Figures from Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer

, 2023
Rajendra Kumar, Janet Mendonca, Olutosin Owoyemi, Kavya Boyapati, Naiju Thomas, Suthicha Kanacharoen, Max Coffey, Deven Topiwala, Carolina Cavaliéri Gomes, Büşra Özbek, Tracy Jones, Marc A. Rosen, Liang Dong, Sadie Wiens, W. Nathaniel Brennen, John T. Isaacs, Angelo M. De Marzo, Mark C. Markowski, Emmanuel S. Antonarakis, David Z. Qian, Kenneth J. Pienta, Drew M. Pardoll, Michael A. Carducci, Samuel R. Denmeade, Sushant K. Kachhap   +24 more
openalex   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Do physiological changes in fatty acid composition alter cellular ferroptosis susceptibility and influence cell function?

Journal of Lipid Research
Ferroptosis is an iron-dependent form of cell death driven by the excessive peroxidation of poly-unsaturated fatty acids (PUFAs) within membrane phospholipids.
Graeme I. Lancaster, Andrew J. Murphy
doaj   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Ferroptosis in plant immunity

Plant Communications
Plant cell death is mediated by calcium, iron, and reactive oxygen species (ROS) signaling in plant immunity. The reconstruction of a nucleotide-binding leucine-rich-repeat receptor (NLR) supramolecular structure, called the resistosome, is intimately involved in the hypersensitive response (HR), a type of cell death involved in effector-triggered ...
Nam-Soo Jwa, Byung Kook Hwang
openaire   +2 more sources