Results 201 to 210 of about 147,915 (338)

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Immune cells dying from ferroptosis: mechanisms and therapeutic opportunities. [PDF]

Cell Death Dis
Liu J, Dong R, Yuan B, Xie Y, Feng Z, Zhou S, Luan F, Chen Y.   +7 more
europepmc   +1 more source

Acidogenesis‐Propelled Coordination Transition in Light‐Triggered Fe‐Polyphenol Polymer for Reactive Oxygen Species‐Augmented Antitumor Therapy

Advanced Science, EarlyView.
A novel iron‐polyphenol‐photoacid coordination polymer (FeBPs) is designed to achieve red light‐triggered external acidification and internal coordination regulation, where this light‐controlled acidification induces coordination changes that enhance Fe active site exposure and provide H+ for beneficial Fe3+/Fe2+ conversion, thereby accelerating ROS ...
Ying Wan, Hui Liu, Lin Gao, Guanyu Tan, Kailin Li, Qiwei Tian, Shiping Yang, Lu An   +7 more
wiley   +1 more source

Ferroptosis in cancer: metabolism, mechanisms and therapeutic prospects. [PDF]

Mol Cancer
Wu Y, Li H, Yue K, Jing C, Duan Y.
europepmc   +1 more source

Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11 [PDF]

Ying Cao, Huan Yang, Yan Huang, Jian Lu, Hong Du, Bingying Wang   +5 more
openalex   +1 more source

Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy

Advanced Science, EarlyView.
This review examines engineered fever therapy (EFT) as a novel cancer treatment, harnessing fever's immunomodulatory effects to enhance systemic immune responses. It explores molecular mechanisms, advances in nanotechnology‐driven thermal immunotherapy, and a bioengineered framework for precise, safe fever induction. The paper evaluates EFT's potential
Yang Li, Fulong Man, Jianwei Cheng, Li Chen, Yongyong Li, Haiqing Dong   +5 more
wiley   +1 more source

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review). [PDF]

Oncol Rep
Mouawad N, El Jaafari N, El Sibai M, Abi-Habib RJ.   +3 more
europepmc   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, EarlyView.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Research progress on ferroptosis in drug resistance and therapy of gastric cancer. [PDF]

J Cancer Res Clin Oncol
Liu Y, Jia L, Yang L, Ning Z, Li Y.
europepmc   +1 more source

Inhibition of regulated cell death by cell-penetrating peptides [PDF]

, 2016

core   +1 more source