Results 201 to 210 of about 72,927 (343)

Do physiological changes in fatty acid composition alter cellular ferroptosis susceptibility and influence cell function?

Journal of Lipid Research
Ferroptosis is an iron-dependent form of cell death driven by the excessive peroxidation of poly-unsaturated fatty acids (PUFAs) within membrane phospholipids.
Graeme I. Lancaster, Andrew J. Murphy
doaj  

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

, 2018
Michael M. Gaschler, Alexander A. Andia, Hengrui Liu, J. Csuka, Brisa Hurlocker, Christopher A. Vaiana, Daniel W. Heindel, Dylan S. Zuckerman, Pieter H. Bos, Eduard Reznik, Ling F. Ye, Yulia Y. Tyurina, Annie Lin, Mikhail S. Shchepinov, Amy Chan, Eveliz Peguero-Pereira, Maksim A. Fomich, Jacob D. Daniels, Andrei V. Bekish, Vadim V. Shmanai, Valerian E. Kagan, Lara K. Mahal, K. A. Woerpel, Brent R. Stockwell   +23 more
openalex   +2 more sources

A ferroptosis–based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis [PDF]

, 2019
David Devos, Caroline Moreau, Maëva Kyheng, Guillaume Garçon, Anne‐Sophie Rolland, Hélène Blasco, Patrick Gelé, Timothée Lenglet, Charlotte Veyrat‐Durebex, Philippe Corcia, Mary Dutheil, Peter Bede, Andreas Jeromin, Patrick Oeckl, Markus Otto, Vincent Meininger, Véronique Danel-Brunaud, Jean-Christophe Devedjian, James A. Duce, Pierre Pradat   +19 more
openalex   +1 more source

Role of GPX4-Mediated Ferroptosis in the Sensitivity of Triple Negative Breast Cancer Cells to Gefitinib [PDF]

, 2020
Xiang Song, Xinzhao Wang, Zhaoyun Liu, Zhiyong Yu   +3 more
openalex   +1 more source

IRE1α Determines Ferroptosis Sensitivity Through Regulation of Glutathione Synthesis [PDF]

Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein ...
Bam, Rakesh, Gan, Boyi, Guo, Youming, Iwawaki, Takao, Jiang, Dadi, Koong, Albert C, Lee, Hyemin, Wang, Liang, Wang, Tianyu, Xia, Ling, Yan, Yuelong, Yang, Zhifen   +11 more
core   +1 more source

Senkyunolide I Improves Septicemia‐Induced Brain Dysfunction via Regulating Nrf2 and Astrocyte Activity.

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Senkyunolide I (Sen I) has a protective effect on the blood–brain barrier (BBB) in rats with sepsis‐associated encephalopathy (SAE). This study investigated whether Sen I regulates Nrf2 to ameliorate sepsis‐induced brain dysfunction (SIBD). Sixty rats were randomly assigned into Sham group, SAE group (Model group), SAE + Sen I group (72 mg/kg,
Haohao Cao, Tao Liu, Meixia Xu
wiley   +1 more source

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

, 2018
Ron Shah, Mikhail S. Shchepinov, Derek A. Pratt   +2 more
openalex   +1 more source

Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids [PDF]

, 2019
Elizabeth G. Bromfield, Jessica L. H. Walters, Shenae L. Cafe, Ilana R. Bernstein, Simone J. Stanger, Amanda L. Anderson, R. John Aitken, Eileen A. McLaughlin, Matthew D. Dun, B.M. Gadella, Brett Nixon   +10 more
openalex   +1 more source

Pharmacotranscriptomic Analysis Reveals Novel Drugs and Gene Networks Regulating Ferroptosis in Cancer [PDF]

, 2020
Haitang Yang, Liang Zhao, Yanyun Gao, Feng Yao, Thomas M. Marti, Ralph A. Schmid, Ren‐Wang Peng   +6 more
openalex   +1 more source

GDF10 Regulates Iron‐Dependent Lipid Oxidation in Colorectal Cancer Cells Through Interaction With IGF2

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Background: This study aims to identify genes with a high likelihood of genetic variation, significant expression differences, and prognostic implications in colorectal cancer (CRC) patients. The research also seeks to investigate the role and mechanisms of key genes in CRC through the analysis of health information data and a combination of ...
Kaobin Ouyang, Tianying Huang, Dan Xie, Hailin Xiong   +3 more
wiley   +1 more source