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Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway. [PDF]
Pharmacol Res PerspectLi L +5 more
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Syringaresinol alleviates acetaminophen-induced hepatocyte ferroptosis through the Nrf2/HO-1 pathway by targeting Caveolin-1. [PDF]
Chin MedCao L +10 more
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The Metabolic Underpinnings of Ferroptosis
Cell Metabolism, 2020 Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis. Ferroptosis is unique among the different cell death modalities, as it has been mostly linked to pathophysiological conditions and because several metabolic pathways, such
Jiashuo Zheng, Marcus Conrad
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Cellular and Molecular Neurobiology, 2022
Stroke is a common and serious nervous system disease caused by the rupture or blockage of the cardiovascular system. It causes millions of deaths and disabilities every year, which is a huge burden on humanity. It may be induced by thrombosis, hypertension, hyperlipidemia, hyperglycemia, smoking, advanced age and so on.
Yunfei Xu +5 more
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Stroke is a common and serious nervous system disease caused by the rupture or blockage of the cardiovascular system. It causes millions of deaths and disabilities every year, which is a huge burden on humanity. It may be induced by thrombosis, hypertension, hyperlipidemia, hyperglycemia, smoking, advanced age and so on.
Yunfei Xu +5 more
openaire +2 more sources
Encuentros en la Biología, 2022
La ferroptosis es una muerte celular programada, oxidativa y dependiente de hierro que ha sido recientemente descrita. A pesar del poco tiempo en el que se lleva estudiando, se han hecho grandes hallazgos sobre su regulación y sus implicaciones fisiopatológicas tanto en cáncer como en procesos inflamatorios.
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La ferroptosis es una muerte celular programada, oxidativa y dependiente de hierro que ha sido recientemente descrita. A pesar del poco tiempo en el que se lleva estudiando, se han hecho grandes hallazgos sobre su regulación y sus implicaciones fisiopatológicas tanto en cáncer como en procesos inflamatorios.
openaire +2 more sources
Ferroptosis in Neurological Disease
The Neuroscientist, 2022Iron accumulation in the CNS occurs in many neurological disorders. It can contribute to neuropathology as iron is a redox-active metal that can generate free radicals. The reasons for the iron buildup in these conditions are varied and depend on which aspects of iron influx, efflux, or sequestration that help maintain iron homeostasis are dysregulated.
Samuel David +3 more
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Journal of Leukocyte Biology
Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Analysis of MicroRNAs in Ferroptosis
2023MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that are involved in a wide range of biological processes, including development, differentiation, and disease. They function by binding to the 3' untranslated region (UTR) of target mRNAs, leading to mRNA degradation or translational repression.
John G, Yuen +2 more
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