Results 231 to 240 of about 90,650 (265)
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Journal of Leukocyte Biology
Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Abstract Ferroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation. The ferroptosis mechanism involves complex interactions between fatty acid metabolism, iron metabolism, lipid peroxidation, and antioxidative defense mechanisms.
Yu-Bin Lee +6 more
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Analysis of MicroRNAs in Ferroptosis
2023MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that are involved in a wide range of biological processes, including development, differentiation, and disease. They function by binding to the 3' untranslated region (UTR) of target mRNAs, leading to mRNA degradation or translational repression.
John G, Yuen +2 more
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Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches
Cardiovascular Drugs and TherapyCardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for targeting ferroptosis to prevent and treat CVDs.A ...
Xianpeng, Zhou +9 more
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The chemical basis of ferroptosis
Nature Chemical Biology, 2019Lipid peroxidation underlies the mechanism of oxidative cell death now known as ferroptosis. This modality, distinct from other forms of cell death, has been intensely researched in recent years owing to its relevance in both degenerative disease and cancer.
Marcus Conrad, Derek A. Pratt
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The Journal of Biochemistry
Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent phospholipid peroxidation and is closely related to various diseases. System Xc−, a cystine/glutamate antiporter, and glutathione peroxidase 4 (GPX4) are key molecules in ferroptosis.
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Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent phospholipid peroxidation and is closely related to various diseases. System Xc−, a cystine/glutamate antiporter, and glutathione peroxidase 4 (GPX4) are key molecules in ferroptosis.
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Ferroptosis in mitochondrial cardiomyopathy
Trends in Cell BiologyFerroptosis is a form of necrotic cell death characterized by iron-dependent lipid peroxidation culminating in membrane rupture. Accumulating evidence links ferroptosis to multiple cardiac diseases and identifies mitochondria as important regulators of ferroptosis.
Ahola, S., Langer, T.
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Sweet signaling for ferroptosis
Cell Chemical BiologyA recent study published in Nature Cell Biology by Zhang et al. has uncovered a critical role for O-GlcNAcylation in sensing and regulating ferroptosis.1 Ferroptosis-induced ROS promotes OGT-mediated FOXK2 O-GlcNAcylation, driving its nuclear translocation to upregulate SLC7A11 and suppress cell death.
Fan, Yu, Lingyu, Jiang, Quan, Chen
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Ferroptosis: A Frontier in Osteoporosis
Hormone and Metabolic ResearchAbstractReduced bone mass and degeneration of the microarchitecture of bone tissue are the hallmarks of osteoporosis, a bone metabolic disease that increases skeletal fragility and fracture susceptibility. Osteoporosis is primarily caused by unbalanced bone remodeling, in which bone synthesis ...
Shubhrat, Maheshwari +2 more
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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Cell, 2023Deguang Liang +2 more
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